{"id":142536,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelo-experimental-de-shock-septico-modulacion-del-tnf-alfa-mediante-somatostatina-14\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"modelo-experimental-de-shock-septico-modulacion-del-tnf-alfa-mediante-somatostatina-14","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modelo-experimental-de-shock-septico-modulacion-del-tnf-alfa-mediante-somatostatina-14\/","title":{"rendered":"Modelo experimental de shock septico-modulacion del tnf alfa mediante somatostatina-14."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Alvarez Sanchez Jes\u00fas Antonio <\/strong><\/h2>\n<p>Se analiza si la somatostatina-14 (ss-14) puede modificar la produccion de tnf en un modelo experimental de shock septico inducido con lipopolisacarido bacteriano (lps), y su relacion con los niveles de prostaglandina e2 (pge2) fueron utilizadas 90 ratas wistar (350 +-20g), perfundidas con ss14 (2mg\/h), o suero salino, a 0.1 ml\/h, desde 30 minutos antes y 90 minutos despues del ensayo con lps (0.5 mg\/kg\/n) y primadas con bcg (2.2&#215;10 vfc\/i.P.). Se realizo analisis de dos muestras y correlacion.  la administracion de ss14 redujo los niveles de tnf a los 90 minutos, al ser determinados por elisa (1130+-272 frente 4720+-1278) y por bioensayo (1.0+-0.8 frente 246+-91 uc) (p=0.01).  se incremento los niveles de pge2 a los 30 minutos (225.7+-94.2\/62+-10)y a los 90 minutos (1872+-1250 frente 1009+-612)(p=0.04), existiendo correlacion niveles tnf 90 minutos y pge2 &#8211; 30 minutos (r=0.93;p=0.002) de tipo exponencial, y reciproca con pge2-90 minutos (r=0.84; p=0.07). Por ello, la somatostatina-14 podria desarrollar una respuesta protectora frente a los efectos de la endotoxemia disminuyendo los niveles de tnf, probablemente secundario al aumento precoz y mantenido de los niveles sericos de pge2.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelo experimental de shock septico-modulacion del tnf alfa mediante somatostatina-14.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelo experimental de shock septico-modulacion del tnf alfa mediante somatostatina-14. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Alvarez Sanchez Jes\u00fas Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda no Moreno Azcoita<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Balibrea  Cantero <\/li>\n<li>Jos\u00e9 Antonio Rodr\u00edguez Montes (vocal)<\/li>\n<li>Jos\u00e9 Antonio Solis  Herruzo (vocal)<\/li>\n<li>Pedro Carda Abella (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alvarez Sanchez Jes\u00fas Antonio Se analiza si la somatostatina-14 (ss-14) puede modificar la produccion de tnf en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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