{"id":142749,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/glicerofosfolipidos-de-colina-como-precursores-de-lipidos-bioactivos-estudio-comparativo-entre-celulas-hematopoyeticas-y-neurales\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"glicerofosfolipidos-de-colina-como-precursores-de-lipidos-bioactivos-estudio-comparativo-entre-celulas-hematopoyeticas-y-neurales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/glicerofosfolipidos-de-colina-como-precursores-de-lipidos-bioactivos-estudio-comparativo-entre-celulas-hematopoyeticas-y-neurales\/","title":{"rendered":"Glicerofosfolipidos de colina como precursores de lipidos bioactivos: estudio comparativo entre celulas hematopoyeticas y neurales."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Rodriguez M. Carmen <\/strong><\/h2>\n<p>El metabolismo de los glicerofosfolipidos de colina conduce a la formacion del factor activador de las plaquetas (paf) durante la estimulacion con agonistas de celulas de origen mieloide (neutrofilos humanos, hl60, u937). A pesar de la produccion simultanea de paf y eicosanoides en algunas condiciones, y del efecto inhibitorio concomitante, no hemos podido demostrar la existencia de una fosfolipasa a2 comun para la produccion de ambos tipos de mediadores. La fosfolipasa a2 puede tener un papel regulador de la sintesis de paf por la via de la acetiltransferasa limitando tanto la disponibilidad de uno de sus sustratos como generando potenciales inhibidores (acido araquidonico y sus metabolitos).  estudios con la droga tapsigargina permiten disociar las vias de produccion de paf y eisosanoides. La elevacion mantenida de los niveles de calcio citosolicos es una condicion necesaria y suficiente para la produccion de paf, mientras la salida de acido araquidonico (precursor de eicosanoides) requiere la activacion de la proteina quinasa c.  las celulas de origen linfoide no poseen la maquinaria enzimatica para la produccion de paf, aunque muestran una gran capacidad para su metabolismo a traves de un mecanismo de union e internacion que se bloque por los antagonistas del receptor del paf.  el metabolismo de la fosfatidilcolina en celulas cromafines bovinas muestra gran diferencia con el observado en celulas mieloides, pues no hemos podido demostrar la formacion de autacoides exportables, y si la produccion de un mensajero intracelular, diacilglicerol, en respuesta a la estimulacion por agonistas del receptor muscarinico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Glicerofosfolipidos de colina como precursores de lipidos bioactivos: estudio comparativo entre celulas hematopoyeticas y neurales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Glicerofosfolipidos de colina como precursores de lipidos bioactivos: estudio comparativo entre celulas hematopoyeticas y neurales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Rodriguez M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda no S\u00e1nchez Crespo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Luis Tamargo Men\u00e9ndez <\/li>\n<li>Lisardo Bosc\u00e1 Gomar (vocal)<\/li>\n<li>Fernando Vivanco Mart\u00ednez (vocal)<\/li>\n<li>Javier Garcia Sancho (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Rodriguez M. Carmen El metabolismo de los glicerofosfolipidos de colina conduce a la formacion del factor [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,986,964,17],"tags":[6523,245035,1108,4665,5664,6004],"class_list":["post-142749","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-complutense-de-madrid","category-lipidos","category-quimica","tag-fernando-vivanco-Martinez","tag-garcia-rodriguez-m-carmen","tag-javier-garcia-sancho","tag-juan-luis-tamargo-menendez","tag-lisardo-bosca-gomar","tag-maria-no-sanchez-crespo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/142749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=142749"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/142749\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=142749"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=142749"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=142749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}