{"id":14275,"date":"2001-04-12T00:00:00","date_gmt":"2001-04-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-respiracion-bajo-cargas-moderadas-sobre-el-musculo-esqueletico-dano-inflamacion-y-remodelamiento\/"},"modified":"2001-04-12T00:00:00","modified_gmt":"2001-04-12T00:00:00","slug":"efectos-de-la-respiracion-bajo-cargas-moderadas-sobre-el-musculo-esqueletico-dano-inflamacion-y-remodelamiento","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efectos-de-la-respiracion-bajo-cargas-moderadas-sobre-el-musculo-esqueletico-dano-inflamacion-y-remodelamiento\/","title":{"rendered":"Efectos de la respiraci\u00f3n bajo cargas moderadas sobre el m\u00fasculo esquel\u00e9tico. da\u00f1o, inflamaci\u00f3n y remodelamiento"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Ram\u00f3n Palacio Cornide <\/strong><\/h2>\n<p>La enfermedad pulmonar obstructiva cr\u00f3nica (epoc) se caracteriza por la presencia de cargas respiratorias cr\u00f3nicas en el paciente. Estas cargas inducen da\u00f1o y remodelamiento de los m\u00fasculos respiratorios con el objetivo de hacer m\u00e1s eficiente la ventilaci\u00f3n. A su vez, una ventilaci\u00f3n m\u00e1s eficiente redundar\u00e1 en un mejor intercambio de gases, dificultando la claudicaci\u00f3n de los propios m\u00fasculos respiratorios. En este estudio se aplican a un modelo animal (perro de raza beagle) cargas inspiratorias resistivas intermitentes de intensidad moderada, por un per\u00edodo de tiempo relativamente prolongado, con el fin de simular la situaci\u00f3n cr\u00f3nica que padece el enfermo con epoc.  objetivos  1,- evaluar el da\u00f1o de membrana secundario a la aplicaci\u00f3n de las cargas mencionadas en m\u00fasculos inspiratorios y control.  2,- valorar los efectos de la aplicaci\u00f3n de las cargas resistivas en la remodelaci\u00f3n de dichos m\u00fasculos.  3,- evaluar los efectos modelo experimental sobre la expresi\u00f3n de citocinas inflamatoria tnfalfa y no inflamatoria il10 en los m\u00fasculos estudiados.  materiales y m\u00e9todos  las cargas correspondieron al 15% de la presi\u00f3n inspiratoria m\u00e1xima, aplic\u00e1ndose por 2h d\u00eda, durante 15 d\u00edas. Antes y despu\u00e9s del per\u00edodo de aplicaci\u00f3n de cargas se tomaron muestras de diagrama, intercostal externo y vasto interno (perif\u00e9rico, control). El da\u00f1o fibrilar se evalu\u00f3 por la presencia de fibronectina intracelular mediante t\u00e9cnica de inmunohistoqu\u00edmica con anticuerpos espec\u00edficos. El tipaje y la morfometr\u00eda fibrilar se realizaron mediante la t\u00e9cnica de inmunohistoqu\u00edmica con utilizaci\u00f3n de anticuerpos espec\u00edficos para las isoformas de las cadenas pesadas de miosina (myhc) i y ii. Los mismos anticuerpos fueron utilizados para semicuantificar estas isoformas mediante la t\u00e9cnica de elisa. La expresi\u00f3n de las citocinas tnfalfa e il10 se realiz\u00f3 mediante la t\u00e9cnica de rt-pcr.  resultados  las cargas inspiratoria<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la respiraci\u00f3n bajo cargas moderadas sobre el m\u00fasculo esquel\u00e9tico. da\u00f1o, inflamaci\u00f3n y remodelamiento<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la respiraci\u00f3n bajo cargas moderadas sobre el m\u00fasculo esquel\u00e9tico. da\u00f1o, inflamaci\u00f3n y remodelamiento <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Ram\u00f3n Palacio Cornide <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Gea Guiral<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: sergio Serrano figueras <\/li>\n<li> Broquetas do\u00f1ate joan Mar\u00eda (vocal)<\/li>\n<li>Antonio Ferrer monreal (vocal)<\/li>\n<li>carme Casadevall fust\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Ram\u00f3n Palacio Cornide La enfermedad pulmonar obstructiva cr\u00f3nica (epoc) se caracteriza por la presencia de cargas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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