{"id":14277,"date":"2001-04-12T00:00:00","date_gmt":"2001-04-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/obtencion-de-vacunas-frente-a-infecciones-producidas-por-herpes-simplex-caractera%c2%adsticas-inmunogenicas-de-la-protea%c2%adna-quimerica-gdb\/"},"modified":"2001-04-12T00:00:00","modified_gmt":"2001-04-12T00:00:00","slug":"obtencion-de-vacunas-frente-a-infecciones-producidas-por-herpes-simplex-caractera%c2%adsticas-inmunogenicas-de-la-protea%c2%adna-quimerica-gdb","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/obtencion-de-vacunas-frente-a-infecciones-producidas-por-herpes-simplex-caractera%c2%adsticas-inmunogenicas-de-la-protea%c2%adna-quimerica-gdb\/","title":{"rendered":"Obtenci\u00f3n de vacunas frente a infecciones producidas por herpes simplex: caracter\u00edsticas inmunog\u00e9nicas de la prote\u00edna quim\u00e9rica gdb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Domingo Carrasco <\/strong><\/h2>\n<p>Se han estudiado las caracter\u00edsticas inmunog\u00e9nicas de la prote\u00edna quim\u00e9rica gdb constituida por parte de los extremos aminoterminales de las glicoprote\u00ednas gb y gd de herpes simplex tipo 2 (vhs-2). Para ello esta prote\u00edna quim\u00e9rica se ha obtenido en e.Coli, as\u00ed como las correspondientes prote\u00ednas individuales gbt y gdt. Tras la inmunizaci\u00f3n de ratones balb\/c con estas prote\u00ednas recombinantes se demostr\u00f3 la capacidad de todas ellas para generar una respuesta humoral espec\u00edfica frente a las prote\u00ednas de vhs-2. Del mismo modo, estas prote\u00ednas recombinantes demostraron su capacidad para generar cierta protecci\u00f3n frente a la infecci\u00f3n intravaginal con un aislado cl\u00ednico de vhs-2, siendo esta protecci\u00f3n m\u00e1s evidente cuando ambas prote\u00ednas, ya sea de forma conjunta (gbt+gdt) o formando parte de la estructura quim\u00e9rica gdb, forman parte del ant\u00edgeno de inmunizaci\u00f3n.  as\u00edmismo, se ha construido un pl\u00e1smico capaz de expresar en eucariostas la prote\u00edna quim\u00e9rica gdb (pcgdb), as\u00ed como los pl\u00e1smidos correspondientes a las prote\u00ednas individuales (pcgbt y pcgdt), con el objeto de estudiar su utilidad como vacuna de dna. En primer lugar, se determin\u00f3 in vitro la correcta expresi\u00f3n de las prote\u00ednas codificadas por estos pl\u00e1smidos, demostr\u00e1ndose que las prote\u00ednas recombinantes expresadas se presentan como prote\u00ednas no glicosiladas y localizadas que las prote\u00ednas recombinantes expresadas se presentan como prote\u00ednas no glicosiladas y localizadas en el citoplasma celular. A su vez, la expresi\u00f3n in vitro de estas prote\u00ednas se extingue tras un breve periodo de tiempo, debido probablemente a la degradaci\u00f3n o simplificaci\u00f3n de estos pl\u00e1smidos en el interior celular.  tas la inmunizaci\u00f3n de ratones balb\/c con los distintos pl\u00e1smidos se observ\u00f3 como, a pesar de generar una respuesta humoral espec\u00edfica frente a las prote\u00ednas de vhs-2, esta respuesta es de menor magnitud que la inducida por las correspondientes prote<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Obtenci\u00f3n de vacunas frente a infecciones producidas por herpes simplex: caracter\u00edsticas inmunog\u00e9nicas de la prote\u00edna quim\u00e9rica gdb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Obtenci\u00f3n de vacunas frente a infecciones producidas por herpes simplex: caracter\u00edsticas inmunog\u00e9nicas de la prote\u00edna quim\u00e9rica gdb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Domingo Carrasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Tabares Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garc\u00eda Garc\u00eda Mar\u00eda Jes\u00fas (secretario) <\/li>\n<li>esteban Domingo solans (vocal)<\/li>\n<li> Bautista santacruz Jos\u00e9 m. (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Domingo Carrasco Se han estudiado las caracter\u00edsticas inmunog\u00e9nicas de la prote\u00edna quim\u00e9rica gdb constituida por parte [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,1737,2714,280,15417],"tags":[46025,46023,6959,5645,46024],"class_list":["post-14277","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-inmunologia","category-vacunas","category-virologia","category-virus-neurotropicos","tag-bautista-santacruz-jose-m","tag-cristina-domingo-carrasco","tag-enrique-tabares-lopez","tag-esteban-domingo-solans","tag-garcia-garcia-maria-jesus-secretario"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=14277"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14277\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=14277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=14277"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=14277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}