{"id":14284,"date":"2001-04-12T00:00:00","date_gmt":"2001-04-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-traduccion-por-fosforilacion-del-factor-eif2-en-un-modelo-de-isquemia-en-celulas-pc12\/"},"modified":"2001-04-12T00:00:00","modified_gmt":"2001-04-12T00:00:00","slug":"regulacion-de-la-traduccion-por-fosforilacion-del-factor-eif2-en-un-modelo-de-isquemia-en-celulas-pc12","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/regulacion-de-la-traduccion-por-fosforilacion-del-factor-eif2-en-un-modelo-de-isquemia-en-celulas-pc12\/","title":{"rendered":"Regulaci\u00f3n de la traducci\u00f3n por fosforilaci\u00f3n del factor eif2 en un modelo de isquemia en c\u00e9lulas pc12"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mu\u00f1oz Postigo Francisco Miguel <\/strong><\/h2>\n<p>La isquemia cerebral se origina por una disminuci\u00f3n del flujo sangu\u00edneo hasta niveles que interfieren con la funcionalidad del sistema nervioso, provocando m\u00faltiples alteraciones que llevan a la muerte celular de la zona afectada, entre ellas la inhibici\u00f3n de la s\u00edntesis proteica. La regulaci\u00f3n de la s\u00edntesis de prote\u00ednas se ejerce fundamentalmente a nivel de iniciaci\u00f3n, siendo uno de los mecanismos de regulaci\u00f3n m\u00e1s importantes el secuestro del factor eif2b por fosforilaci\u00f3n de la subunidad alfa del factor eif2.  desde 1994 hemos estado interesados en el estudio de la regulaci\u00f3n de la s\u00edntesis de prote\u00ednas durante la isquemia cerebral, y hemos demostrado que tras un periodo de isquemia cerebral transitorio en ratas, se produce una inhibici\u00f3n de la s\u00edntesis de prote\u00ednas asociado a una disminuci\u00f3n de la actividad del factor eif2b y un aumento de la fosforilaci\u00f3n de la subunidad alfa del factor eif2.  este aumento de fosforilaci\u00f3n puede estar regulado a nivel de prote\u00ednas quinasas o de prote\u00ednas fosfatasas, siendo su estudio complejo en un sistema in vivo, por lo que se utiliza un sistema in vitro en c\u00e9lulas pc12 diferenciadas con factor de crecimiento nervioso (ngf), en el que ya hab\u00edamos demostrado su idoneidad para el estudio de los mecanismos reguladores del proceso de iniciaci\u00f3n de la s\u00edntesis proteica.  por lo tanto el objetivo fundamental de esta tesis doctoral es estudiar los mecanismos implicados en la regulaci\u00f3n de la fosforilaci\u00f3n del factor de iniciaci\u00f3n el eif2 en un modelo de isquemia en c\u00e9lulas pc12 diferenciadas con ngf.  para ello se sigue el siguiente plan de trabajo:  a,- optimizaci\u00f3n del modelo de isquemia en las pc12. Valoraci\u00f3n de la s\u00edntesis de prote\u00ednas y cuantificaci\u00f3n de la fosforilaci\u00f3n de eif2alfa.  b,- estudio de los mecanismos de regulaci\u00f3n de eif2(alfap) tras las isquemia. Implicaci\u00f3n de eif2alfa quinasas y\/o fosfatasas.  c,- estudio de la muerte celular inducida p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la traducci\u00f3n por fosforilaci\u00f3n del factor eif2 en un modelo de isquemia en c\u00e9lulas pc12<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la traducci\u00f3n por fosforilaci\u00f3n del factor eif2 en un modelo de isquemia en c\u00e9lulas pc12 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mu\u00f1oz Postigo Francisco Miguel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>fando Castro Juan  Jos\u00e9 L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Arilla ferreiro <\/li>\n<li>Rafael Mart\u00edn del r\u00edo (vocal)<\/li>\n<li> Sierra p\u00e9rez Jos\u00e9 Manuel (vocal)<\/li>\n<li>Luis Del peso ovalle (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mu\u00f1oz Postigo Francisco Miguel La isquemia cerebral se origina por una disminuci\u00f3n del flujo sangu\u00edneo hasta niveles [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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