{"id":143385,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tolerancia-y-dependencia-a-opioides-a-nivel-del-plexo-mienterico-papel-del-calcio\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"tolerancia-y-dependencia-a-opioides-a-nivel-del-plexo-mienterico-papel-del-calcio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tolerancia-y-dependencia-a-opioides-a-nivel-del-plexo-mienterico-papel-del-calcio\/","title":{"rendered":"Tolerancia y dependencia a opioides a nivel del plexo mienterico. papel del calcio"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Vicente Garaulet Rodriguez <\/strong><\/h2>\n<p>En la actualidad no se conocen con exactitud los mecanismos y el tipo de receptor opioide (ro) implicados en los procesos de tolerancia y dependencia a opioides.  por tanto, los objetivos de esta tesis fueron:  1) estudiar el tipo de ro implicado en el desarrollo de tolerancia y dependencia fisica a opioides.  2) analizar el posible desarrollo de tolerancia y\/o dependencia cruzada u\/k y k\/u.  3) valorar la participacion del calcio en la instauracion de tolerancia a agonistas u y k.  para realizar estos objetivos utilizamos la preparacion musculo longitudinal plexo mienterico de ileon de cobya ya que ha sido descrita como una preparacion optima para el estudio de los efectos tanto agudos como cronicos de los opioides.  nuestro resultados demuestran que tras la activacion cronica con morfina (agonista preferentemente u), sufentanil (agonista-u selectivo) o u-50,488h (agonista-k selectivo) se produce tolerancia al efecto inhibitorio de morfina, damgo, sufentanil o u-50,488h. Esta tolerancia se evidencia por un desplazamiento de las curvas dosis-respuesta obtenidas en tiras de ileon procedentes de cobayas tratados cronicamente con agonistas opioides respecto a los controles y por un aumento de la ci50 observandose a veces una disminucion del efecto maximo y\/o de la pendiente curva. El desarrollo de tolerancia se acompa\u00f1o de dependencia fisica que se evidencio tras la addiccion al ba\u00f1o de diferentes antagonistas opioides (naloxona, mr-2266 o nor-binaltorfimina).  el tratamiento cronico con dihidropiridinas modifico el desarrollo de tolerancia al efecto inhibitorio de sufentanil y u-50, 488h. Nimodipina (antagonista de los canales de calcio) potencio la tolerancia inducida con los agonistas u o k mientras que el bay k 8644 (agonista de los canales de calcio) disminuyo la magnitud de la tolerancia al efecto de los agonistas opioides.  en conclusion nuestros datos demuestranz: 1) los receptores u y k estan implicados en la i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tolerancia y dependencia a opioides a nivel del plexo mienterico. papel del calcio<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tolerancia y dependencia a opioides a nivel del plexo mienterico. papel del calcio <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Vicente Garaulet Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Victoria Milan\u00e9s Maquil\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Puig Riera De Conias Margarita <\/li>\n<li>Alfonso Carvajal Garcia-pando (vocal)<\/li>\n<li>Mar\u00eda  Amor Hurle  Gonzalez (vocal)<\/li>\n<li>Jes\u00fas Llenas Calvo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Vicente Garaulet Rodriguez En la actualidad no se conocen con exactitud los mecanismos y el tipo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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