{"id":143390,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/investigacion-de-un-componente-purinergico-en-el-mecanismo-de-accion-de-los-digitalicos\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"investigacion-de-un-componente-purinergico-en-el-mecanismo-de-accion-de-los-digitalicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/investigacion-de-un-componente-purinergico-en-el-mecanismo-de-accion-de-los-digitalicos\/","title":{"rendered":"Investigacion de un componente purinergico en el mecanismo de accion de los digitalicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Garcia Navarro <\/strong><\/h2>\n<p>Dada la similitud existente entre los mecanismos y efectos electrofisiologicos entre la adenosina y los digitalicos, proponemos la hipotesis de que en la accion electrofisiologica de la digital sobre el nodo auriculo &#8211; ventricular existe un componente purinergico. Para someter a prueba experimental dicha hipotesis se realizaron 25 experimentos en perros anestesiados; mediante cateterismo derecho se registro el electrograma de his y se midio el intervalo de conduccion nodal (intervalo a-h). En la auricula derecha se aplico estimulacion electrica a diferentes rangos de frecuencia (3.5, 4, 4.5 y 5 hz).  se administro ouabaina a dosis de 0.001 mg\/kg\/min hasta alcanzar la dosis letal. Las curvas dosis\/respuesta de la ouabaina sobre el intervalo de conduccion a-h se desplazaron hacia la izquierda y hacia arriba por accion del dipiridamol (bloqueante del transporte de nucleosifos) a dosis de 0.5 mg\/kg y hacia abajo y a la derecha por accion de la aminofilina (antagonista competitivo de la adenosina) a dosis de 20 mg\/kg. , hechos que apoyan la hipotesis planteada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Investigacion de un componente purinergico en el mecanismo de accion de los digitalicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Investigacion de un componente purinergico en el mecanismo de accion de los digitalicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Garcia Navarro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Arturo Brugger Auban<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Garcia Morilla <\/li>\n<li>Juan  Antonio Ruiperez Abizanda (vocal)<\/li>\n<li> Castillo Ferrando Juan  Ram\u00f3n (vocal)<\/li>\n<li> Del Rio Martinez Jes\u00fas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Garcia Navarro Dada la similitud existente entre los mecanismos y efectos electrofisiologicos entre la adenosina y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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