{"id":14381,"date":"2001-11-12T00:00:00","date_gmt":"2001-11-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/accion-proliferativa-diferenciadora-sobre-supervivencia-y-preventiva-de-apoptosis-del-sistema-gh-igf-i-en-celulas-cerebrales-fetales\/"},"modified":"2001-11-12T00:00:00","modified_gmt":"2001-11-12T00:00:00","slug":"accion-proliferativa-diferenciadora-sobre-supervivencia-y-preventiva-de-apoptosis-del-sistema-gh-igf-i-en-celulas-cerebrales-fetales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/accion-proliferativa-diferenciadora-sobre-supervivencia-y-preventiva-de-apoptosis-del-sistema-gh-igf-i-en-celulas-cerebrales-fetales\/","title":{"rendered":"Acci\u00f3n proliferativa, diferenciadora, sobre supervivencia y preventiva de apoptosis del sistema gh-igf-i en c\u00e9lulas cerebrales fetales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rocio Ajo Ramos <\/strong><\/h2>\n<p>Los mecanismos que controlan la diferenciaci\u00f3n y desarrollo del sistema nervioso central no est\u00e1n claramente establecidos. Un \u00e1rea de inter\u00e9s y poco conocida es la implicaci\u00f3n del sistema gh-igf-i en el desarrollo cerebral. a pesar de la identificaci\u00f3n del receptor de hormona de crecimiento (ghr) y su arnm en hemisferio cerebral de rata y otras zonas del sistema nervioso central (snc), su papel fisiol\u00f3gico como factor neurotr\u00f3fico en el mismo no est\u00e1 establecido. El objetivo fundamental de este trabajo es estudiar las acciones neurotr\u00f3ficas que la hormona de crecimiento (gh) pudiera ejercer en el desarrollo del snc, analizar la posible implicaci\u00f3n de igf-i como mediador de sus acciones y dilucidar la v\u00eda de se\u00f1alizaci\u00f3n predominante en las acciones biol\u00f3gicas de gh. Para ello se han empleado c\u00e9lulas cerebrocorticales de feto de rata procedentes de los d\u00edas fetales e14 y e17 y se han llevado a cabo estudios de proliferaci\u00f3n, diferenciaci\u00f3n, prevenci\u00f3n de apoptosis y de se\u00f1alizaci\u00f3n intracelular. Para todos los estudios se ha utilizado hormona de crecimiento recombinante humana que tiene 100% de acci\u00f3n biol\u00f3gica en rata.  los resultados obtenidos demuestran que:  1,- gh ejerce una acci\u00f3n potente sobre la proliferaci\u00f3n de c\u00e9lulas cerebrocorticales fetales de rata en cultivo primario mixto. Ello se demuestra mediante contaje celular, cuantificaci\u00f3n de pcna, incorporaci\u00f3n de timidina-3h e incorporaci\u00f3n de brdu. Esta acci\u00f3n ocurre a dosis cr\u00edticas siendo m\u00e1s intensa en concentraciones fisiol\u00f3gicas.  2,- la hormona de crecimiento induce una potente acci\u00f3n proliferativa sobre c\u00e9lulas precursoras y neuronales procedentes del d\u00eda e14 y sobre c\u00e9lulas gliales procedentes del d\u00eda e17. Ello evidencia la acci\u00f3n de gh en los distintos momentos cronol\u00f3gicos de la neurog\u00e9nesis y gliog\u00e9nesis en cerebro de rata.  3,- la hormona de crecimiento promueve la diferenciaci\u00f3n de c\u00e9lulas precursoras cerebrocorticales<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Acci\u00f3n proliferativa, diferenciadora, sobre supervivencia y preventiva de apoptosis del sistema gh-igf-i en c\u00e9lulas cerebrales fetales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Acci\u00f3n proliferativa, diferenciadora, sobre supervivencia y preventiva de apoptosis del sistema gh-igf-i en c\u00e9lulas cerebrales fetales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rocio Ajo Ramos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mart\u00edn S\u00e1nchez Franco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Miguel Garc\u00eda segura <\/li>\n<li>gumersindo Fernandez vazquez (vocal)<\/li>\n<li>rosa Mar\u00eda Tol\u00f3n rafael (vocal)<\/li>\n<li>predestinaci\u00f3n Garc\u00eda p\u00e9rez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rocio Ajo Ramos Los mecanismos que controlan la diferenciaci\u00f3n y desarrollo del sistema nervioso central no est\u00e1n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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