{"id":14394,"date":"2001-12-12T00:00:00","date_gmt":"2001-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-del-transforming-growth-factor-beta-1-en-el-sa%c2%adndrome-de-isquemia-reperfusion-en-un-modelo-de-trasplante-experimental-a-corazon-parado-en-cerdos\/"},"modified":"2001-12-12T00:00:00","modified_gmt":"2001-12-12T00:00:00","slug":"expresion-del-transforming-growth-factor-beta-1-en-el-sa%c2%adndrome-de-isquemia-reperfusion-en-un-modelo-de-trasplante-experimental-a-corazon-parado-en-cerdos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-del-transforming-growth-factor-beta-1-en-el-sa%c2%adndrome-de-isquemia-reperfusion-en-un-modelo-de-trasplante-experimental-a-corazon-parado-en-cerdos\/","title":{"rendered":"Expresi\u00f3n del transforming growth factor beta 1 en el s\u00edndrome de isquemia-reperfusi\u00f3n en un modelo de trasplante experimental a coraz\u00f3n parado en cerdos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rios Mendes Francisco Diogo <\/strong><\/h2>\n<p>Existen evidencias que sugieren que el tgf-beta1 juega un papel importante en la patog\u00e9nesis y fibrosis en la nefropat\u00eda cr\u00f3nica del injerto. No obstante, el papel fisiol\u00f3gico que juega el tgf-beta1 en las fases iniciales del trasplante no est\u00e1 todav\u00eda adecuadamente aclarado. El objetivo de la tesis fue estudiar dicho tgf-beta1 y otros marcadores que son factores relevantes en la lesi\u00f3n por isquemia-reperfusi\u00f3n, durante el postrasplante renal inmediato de donante a coraz\u00f3n parado.  cuarenta parejas (donante-receptor) de cerdo ib\u00e9rico fueron distribuidos en 4 grupos:  grupo i: sin isquemia caliente (ic grupo control).  grupo ii: sometidos a 30 min., A ic.  grupo iii: sometidos a 45 min., A ic.  grupo iv: sometidos a 90 min., A ic.  todos los grupos fueron sometidos a 6h de isquemia fr\u00eda (if) hasta el trasplante, durante el que se extrajeron las muestras (sangre y tejido) en los momentos que se denominaron basal (justo despu\u00e9s de estabilizar al animal), ic, if, i-r (1 hora despu\u00e9s de la reperfusi\u00f3n) y al momento final, al quinto d\u00eda (5d), despu\u00e9s de dicho trasplante, cuando los animales supervivientes hab\u00eda sido ya sacrificados. La expresi\u00f3n del tgf-beta1 fue medida por el m\u00e9todo de la pcr cuantitativa. La concentraci\u00f3n de atp, adp y amp fueron determinadas en tejido renal por medidas de cromatograf\u00eda l\u00edquida de alta presi\u00f3n (hplc) en fase reversa. La carga energ\u00e9tica (ec) fue calculada. El flujo renal arterial fue calculado en el donante, y despu\u00e9s de reperfusi\u00f3n en el receptor mediante un probe electromagn\u00e9tico (transonic(r)). la presencia de necrosis cortical fue utilizada como criterio de viabilidad.  los niveles del tgf-beta1 mrna aumentaron significativamente en el postoperatorio inmediato al trasplante renal (5d) en todos los frupos estudiados. Estos resultados sugieren que la isquemia fr\u00eda \u00abper se\u00bb hizo aumentar la expresi\u00f3n del tgf-beta1. Los tiempos progresivos de isquemia caliente no indujeron<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n del transforming growth factor beta 1 en el s\u00edndrome de isquemia-reperfusi\u00f3n en un modelo de trasplante experimental a coraz\u00f3n parado en cerdos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n del transforming growth factor beta 1 en el s\u00edndrome de isquemia-reperfusi\u00f3n en un modelo de trasplante experimental a coraz\u00f3n parado en cerdos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rios Mendes Francisco Diogo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>vijande Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pablo Carretero gonz\u00e1lez <\/li>\n<li> I\u00f1igo gil pablo j. (vocal)<\/li>\n<li>antoni Gelabert mas (vocal)<\/li>\n<li>octavio Arango toro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rios Mendes Francisco Diogo Existen evidencias que sugieren que el tgf-beta1 juega un papel importante en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,160,115,9,141,10,1279,1533,17],"tags":[1326,46350,46351,1046,46348,46349],"class_list":["post-14394","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-bioquimica","category-bioquimica-molecular","category-ciencias-medicas","category-cirugia","category-cirugia-de-trasplantes","category-cirugia-experimental","category-cirugia-urologica","category-quimica","tag-antoni-gelabert-mas","tag-inigo-gil-pablo-j","tag-octavio-arango-toro","tag-pablo-carretero-gonzalez","tag-rios-mendes-francisco-diogo","tag-vijande-alvarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=14394"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14394\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=14394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=14394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=14394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}