{"id":144102,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-biodisponibilidad-oral-de-la-amoxicilina-en-la-rata\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"estudio-de-la-biodisponibilidad-oral-de-la-amoxicilina-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-biodisponibilidad-oral-de-la-amoxicilina-en-la-rata\/","title":{"rendered":"Estudio de la biodisponibilidad oral de la amoxicilina en la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Chesa Jimenez <\/strong><\/h2>\n<p>El trabajo descrito ha estudiado las causas que motivan la baja biodisponibilidad oral de la amoxicilina en la rata. En primer lugar se determino la biodisponibilidad oral de la amoxicilina a partir del farmaco inalterado excretado en la orina, obteniendose una biodisponibilidad del 52,1%. Seguidamente, se procedio al estudio del efecto de primer paso hepatico, para lo cual se desarrollo una tecnica que se describe, concluyendo que la amoxicilina no sufre efecto de primer paso hepatico en la rata. Tras comprobar la escasa influencia de la microflora intestinal en la biodisponibilidad del antibiotico, se realizo una serie de estudios encaminados a determinar la fraccion de dosis no absorbida y la posible existencia de una zona intestinal de absorcion selectiva para el antibiotico, comprobando que la absorcion de la amoxicilina en la rata se realiza, preferentemente, en los dos tercios distales del intestino delgado. Finalmente, en ensayos in vitro incubando el antibiotico en diferentes condiciones experimentales, se observo una considerable degradacion del farmaco cuando la incubacion se realizo en presencia de tejido intestinal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la biodisponibilidad oral de la amoxicilina en la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la biodisponibilidad oral de la amoxicilina en la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Chesa Jimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Peris Ribera Jos\u00e9 E.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Zaragoza Garcia <\/li>\n<li>Jes\u00fas Renedo M. (vocal)<\/li>\n<li>Adela Mart\u00edn Villodr\u00e9 (vocal)<\/li>\n<li>Miguel Marti Cabrera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Chesa Jimenez El trabajo descrito ha estudiado las causas que motivan la baja biodisponibilidad oral de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,9,189],"tags":[12340,4080,258865,258802,198622,11834],"class_list":["post-144102","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","tag-adela-martin-villodre","tag-francisco-zaragoza-garcia","tag-jesus-chesa-jimenez","tag-jesus-renedo-m","tag-miguel-marti-cabrera","tag-peris-ribera-jose-e"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/144102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=144102"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/144102\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=144102"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=144102"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=144102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}