{"id":144103,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/toxicidad-y-farmacocinetica-intraocular-de-la-ciclosporina-a-estudio-clinico-experimental\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"toxicidad-y-farmacocinetica-intraocular-de-la-ciclosporina-a-estudio-clinico-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/toxicidad-y-farmacocinetica-intraocular-de-la-ciclosporina-a-estudio-clinico-experimental\/","title":{"rendered":"Toxicidad y farmacocinetica intraocular de la ciclosporina a. estudio clinico-experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enrique Chipont Benabent <\/strong><\/h2>\n<p>La ciclosporina a ha demostrado eficacia clinica y experimental cuando es administrada de forma local. El conocimiento exacto de este efecto local y el futuro uso clinico de la ciclosporina pasa de una forma obligada por establecer su famecocinetica y toxicidad.  hemos desarrollado un modelo de administracion sistemica en 60 pacientes y otro de administracion topica en 70 pacientes, intervenidos por diferentes patolog\u00edas para establecer la farmacocinetica intraocular de la ciclosporina a en los diferentes fluidos oculares. Por otro lado, hemos desarrollado un modelo de inyeccion intravitrea del farmaco en 66 conejos para establecer los niveles de toxicidad y la farmacocinetica de las dosis no toxicas.  nuestros resultados permiten establecer la existencia de una cinetica de eliminacion monoexponencial de la ciclosporina a en todos los fluidos oculares, alcanzando unicamente niveles terapeuticos minimos en liquido subretiniano, relacionados ademas con los plasmaticos. A nivel topico, la administracion del colirio de ciclosporina junto a escudos de colageno corneal potencia en 1.8 veces la penetracion intraocular aunque sin alcanzar niveles terapeuticos. La administracion intravitrea del farmaco en conejos, presenta ausencia de toxicidad con dosis de 100 mcgr. De ciclosporina de la solucion endovenosa comercializada y cinetica de eliminacion bioesponencial; el uso de la solucion oral comercializada presenta ausencia de toxicidad con 1000 mcgr. Y cinetica de eliminacion de orden o.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Toxicidad y farmacocinetica intraocular de la ciclosporina a. estudio clinico-experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Toxicidad y farmacocinetica intraocular de la ciclosporina a. estudio clinico-experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enrique Chipont Benabent <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Menezo Rozalen<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pilar Ivorra Lahuerta <\/li>\n<li>Antonia Fons Moreno (vocal)<\/li>\n<li>Justo Medrano Heredia (vocal)<\/li>\n<li>Julio De La Camara Hermoso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enrique Chipont Benabent La ciclosporina a ha demostrado eficacia clinica y experimental cuando es administrada de forma [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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