{"id":14423,"date":"2001-12-12T00:00:00","date_gmt":"2001-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/puncion-aspiracion-con-aguja-fina-de-tumores-hepaticos-valor-diagnostico-y-reproducibilidad-de-criterios-citologicos-y-analisis-del-contenido-de-dna-por-citometria-de-flujo\/"},"modified":"2001-12-12T00:00:00","modified_gmt":"2001-12-12T00:00:00","slug":"puncion-aspiracion-con-aguja-fina-de-tumores-hepaticos-valor-diagnostico-y-reproducibilidad-de-criterios-citologicos-y-analisis-del-contenido-de-dna-por-citometria-de-flujo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/puncion-aspiracion-con-aguja-fina-de-tumores-hepaticos-valor-diagnostico-y-reproducibilidad-de-criterios-citologicos-y-analisis-del-contenido-de-dna-por-citometria-de-flujo\/","title":{"rendered":"Punci\u00f3n-aspiraci\u00f3n con aguja fina de tumores hep\u00e1ticos. valor diagn\u00f3stico y reproducibilidad de criterios citol\u00f3gicos y an\u00e1lisis del contenido de dna por citometr\u00eda de flujo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosario Granados Carre\u00f1o <\/strong><\/h2>\n<p>Existen muchos criterios citol\u00f3gicos importantes en el diagn\u00f3stico de masas hep\u00e1ticas por punci\u00f3n-aspiraci\u00f3n con aguja fina (paaf), pero ninguno de ellos es patogenom\u00f3nico de un diagn\u00f3stico de benignidad o de malignidad primaria o metast\u00e1sica. En este estudio analizamos el valor diagn\u00f3stico y la reproducibilidad de 28 par\u00e1metros citol\u00f3gicos en una muestra de 140 casos que incluyen 29 lesiones benignas, 49 carcinomas hepatocelulares (chcs) y 62 tumores metast\u00e1sicos, 49 de ellos adenocarcinomas (acas). Cinco observadores distintos evaluaron cada muestra y se analiz\u00f3 el acuerdo interobservador e intraobservador. En 39 muestras (5 benignas, 9 chcs y 25 met\u00e1stasis) se estudi\u00f3 el contenido de dna de forma prospectiva mediante citometr\u00eda de flujo (cmf). El an\u00e1lisis multivariante de los datos citol\u00f3gicos seleccion\u00f3 el contorno nuclear irregular, los grupos tridimensionales y los n\u00facleos at\u00edpicos sueltos como los criterios m\u00e1s estrechamente asociados a malignidad. la presencia de capilares separando c\u00e9lulas tumorales y el citoplasma granular estaban fundamentalmente asociados al chc, mientras que los n\u00facleos exc\u00e9ntricos y la necrosis eran los dos criterios clave para el diagn\u00f3stico de carcinoma metast\u00e1sico. Los acuerdos intraobservador e interobservador fueron excelentes para el diagn\u00f3stico citol\u00f3gico final. Los criterios arquitecturales eran menos reproducibles que los criterios citol\u00f3gicos cl\u00e1sicos. La variabilidad intraobservador no se vio afectada por los a\u00f1os de experiencia del observador. la sensibilidad y la especificidad del test citol\u00f3gico fue excelente (100 y 97% respectivamente). Todos los casos benignos eran diploides, mientras que el 55,6% de chcs y el 36% de tumores metast\u00e1sicos mostraban una distribuci\u00f3n aneuploide. La ploid\u00eda no discriminaba entre benigno y maligno, pero la fracci\u00f3n s proliferativa s\u00ed. Los niveles s\u00e9ricos de alfa-fetoprote\u00edna (afp) no mostraban correlaci\u00f3n con el contenido de d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Punci\u00f3n-aspiraci\u00f3n con aguja fina de tumores hep\u00e1ticos. valor diagn\u00f3stico y reproducibilidad de criterios citol\u00f3gicos y an\u00e1lisis del contenido de dna por citometr\u00eda de flujo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Punci\u00f3n-aspiraci\u00f3n con aguja fina de tumores hep\u00e1ticos. valor diagn\u00f3stico y reproducibilidad de criterios citol\u00f3gicos y an\u00e1lisis del contenido de dna por citometr\u00eda de flujo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosario Granados Carre\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pilar Fern\u00e1ndez Segoviano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: juliana Fari\u00f1a gonz\u00e1lez <\/li>\n<li>Jes\u00fas Fernando Gonzalez-palacios Martinez (vocal)<\/li>\n<li>josef\u00edna Men\u00e9ndez s\u00e1nchez (vocal)<\/li>\n<li>xavier Matias-guiu guia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosario Granados Carre\u00f1o Existen muchos criterios citol\u00f3gicos importantes en el diagn\u00f3stico de masas hep\u00e1ticas por punci\u00f3n-aspiraci\u00f3n con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,1027,156],"tags":[46437,7667,6163,46436,46435,46438],"class_list":["post-14423","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-oncologia","category-patologia","tag-jesus-fernando-gonzalez-palacios-Martinez","tag-josefina-menendez-sanchez","tag-juliana-farina-gonzalez","tag-pilar-fernandez-segoviano","tag-rosario-granados-carreno","tag-xavier-matias-guiu-guia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=14423"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14423\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=14423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=14423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=14423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}