{"id":144244,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tecnicas-de-hibridacion-con-marcaje-enzimatico-estudio-de-los-oncogenes-c-myc-c-h-ras-y-c-neu-en-canceres-humanos-de-mama-y-pulmon\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"tecnicas-de-hibridacion-con-marcaje-enzimatico-estudio-de-los-oncogenes-c-myc-c-h-ras-y-c-neu-en-canceres-humanos-de-mama-y-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/tecnicas-de-hibridacion-con-marcaje-enzimatico-estudio-de-los-oncogenes-c-myc-c-h-ras-y-c-neu-en-canceres-humanos-de-mama-y-pulmon\/","title":{"rendered":"Tecnicas de hibridacion con marcaje enzimatico: estudio de los oncogenes c-myc, c-h-ras y c-neu en canceres humanos de mama y pulmon"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ricardo Molina Gasset <\/strong><\/h2>\n<p>Se estudia la presencia de amplificaciones y\/o rearreglos de los oncogenes c-h-ras, c-myc y c-neu, para lo cual se pone a punto un metodo de hibridacion de adn empleando sondas marcadas con digoxigenina. El metodo desarrollado tiene la especificidad, sensibilidad y precision adecuadas. De un total de 218 canceres de mama (cms), se ha detectado amplificacion de c-neu en un 23.9%, de c-myc en un 13.1% y ninguna amplificacion o rearreglos de c-h-ras. La presencia de amplificaciones del c-myc esta fuertemente asociada con los cms re-, de peor pronostico.  la tendencia de rfce mas elevados en los cms myc+ y la mayor amplificacion con el aumento del indice de scaff-bloom, confieren al c-myc un caracter de mal pronostico. La mayor concentracion de rfce y el mayor grado de infiltracion ganglionar en los cms neu+\/rfce+, junto con mayor amplificacion de c-neu en los cms rfce+\/n+, asocian al oncogen con el mal pronostico. La amplificacion de c-neu diferencia dos grupos en los cms re-, los neu+ y neu-, con mayor y menor proporcion de ganglios afectados respectivamente, siendo la interaccion neu-re de factor pronostico independiente. Se relaciona al c-neu con la agresividad e indiferenciacion tumoral, por encontrarse mayor amplificacion en los cms m1, asi como aumento del grado de amplificacion con el indice de scarff-bloom. No se encuentran amplificaciones de los oncogenes, estudiados en los tejidos peritumorales sanos y se hallan 3 amplificaciones de c-neu y 2 de c-myc en los 27 canceres de pulmon (cps). La amplificacion de c-myc parece relacionarse con el mal pronostico en el cp puesto que se asocia con el tama\u00f1o tumoral, la presencia de metastasis y ile mas cortos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tecnicas de hibridacion con marcaje enzimatico: estudio de los oncogenes c-myc, c-h-ras y c-neu en canceres humanos de mama y pulmon<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tecnicas de hibridacion con marcaje enzimatico: estudio de los oncogenes c-myc, c-h-ras y c-neu en canceres humanos de mama y pulmon <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ricardo Molina Gasset <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pascual Bolufer Gilabert<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Javier Boix Ferrero <\/li>\n<li>Rafael Molina Porto (vocal)<\/li>\n<li>Guillermo Saez Tormo (vocal)<\/li>\n<li>Francisco Palau Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ricardo Molina Gasset Se estudia la presencia de amplificaciones y\/o rearreglos de los oncogenes c-h-ras, c-myc y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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