{"id":144286,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/proteinas-de-membrana-externa-omp-de-bacterias-gramnegativas-hospitalarias-resistentes-a-quinolonas-y-carbapenemicos-aplicaciones-y-significacion\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"proteinas-de-membrana-externa-omp-de-bacterias-gramnegativas-hospitalarias-resistentes-a-quinolonas-y-carbapenemicos-aplicaciones-y-significacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/proteinas-de-membrana-externa-omp-de-bacterias-gramnegativas-hospitalarias-resistentes-a-quinolonas-y-carbapenemicos-aplicaciones-y-significacion\/","title":{"rendered":"Proteinas de membrana externa (omp) de bacterias gramnegativas hospitalarias resistentes a quinolonas y carbapenemicos: aplicaciones y significacion"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Perez Saborit Francisco Javier <\/strong><\/h2>\n<p>Los mecanismos de resistencia en bacterias gramnegativas mediados por disminucion en la permeabilidad a traves de su membrana externa, en un conjunto de proteinas conocidas como porinas son un factor de primer orden en la resistencia intrinseca de pseudomonas aeruginosa y acinetobacter calcoaceticus. Asimismo las alteraciones en la dna-girasa, sobretodo en la sub-unidad a son de gran importancia en la resistencia a fluoroquinolonas. Hemos estudiado las proteinas de membrana externa de diferentes aislados del hospital clinico universitario de Valencia de las especies p. Aeruginosa, e. Coli y acinetobacter calcoaceticus en relacion con la sensibilidad que presentan tales aislados. Asimismo hemos estudiado genes de resistencia por amplificacion enzimatica del dna (pcr). En concreto hemos amplificado los genes que codifican para las porinas omp f, omp c y pho e de nuestros aislados de e. Coli y opr f en nuestros aislados de p. Aeruginosa y para la subunidad a de la dna-girasa de e. Coli. Los amplificados han sido sometidos a digestion con endonucleasas de restriccion intentanto relacionar los diferentes perfiles obtenidos con la sensibilidad de los aislados. En p. Aeruginosa hemos encontrado un menor nivel de expresion de las proteinas de membrana externa opr d 2 y opr c en nuestros aislados moderadamente sensibles o resistentes a imipenem o ciprofloxacino, en comparacion con aislados susceptible.  otras proteinas de la membrana externa de esta bacteria han sido exresadas en todos los aislados en concreto opr e y opr f. Los perfiles de restriccion encontrados en aislados resistentes a ciprofloxacino en el locus gyr a de la dna-girasa de e. Coli son muy especificos de estos aislados. En los genes de resistencia de p. Aeruginosa amplificados (opr f) no existe relacion entre los perfiles de restriccion obtenidos y la sensibilidad de los aislados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Proteinas de membrana externa (omp) de bacterias gramnegativas hospitalarias resistentes a quinolonas y carbapenemicos: aplicaciones y significacion<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Proteinas de membrana externa (omp) de bacterias gramnegativas hospitalarias resistentes a quinolonas y carbapenemicos: aplicaciones y significacion <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Perez Saborit Francisco Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Garcia De Lomas Barrionuevo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Federico Uruburu Fern\u00e1ndez <\/li>\n<li>Javier Aznar Martin (vocal)<\/li>\n<li>Miguel Gobernado Serrano (vocal)<\/li>\n<li>Federico Alcacer Garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Perez Saborit Francisco Javier Los mecanismos de resistencia en bacterias gramnegativas mediados por disminucion en la permeabilidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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