{"id":14444,"date":"2018-03-09T09:01:09","date_gmt":"2018-03-09T09:01:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-de-la-reparacion-de-sitios-abasicos-en-el-dna-de-leishmania-major\/"},"modified":"2018-03-09T09:01:09","modified_gmt":"2018-03-09T09:01:09","slug":"caracterizacion-molecular-de-la-reparacion-de-sitios-abasicos-en-el-dna-de-leishmania-major","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-molecular-de-la-reparacion-de-sitios-abasicos-en-el-dna-de-leishmania-major\/","title":{"rendered":"Caracterizaci\u00f3n molecular de la reparaci\u00f3n de sitios ab\u00e1sicos en el dna de leishmania major"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Claribel Gallego Garc\u00eda <\/strong><\/h2>\n<p>El protozzo par\u00e1sito leishmania major es el agente causal de una de las enfermedades infecciosas que afectan a mayor n\u00famero de personas a nivel mundial. Actualmente existen alrededor de 350 millones de individuos expuestos a al enfermedad, de los cuales cerca de 12 millones la minifiestan, apariciendo 1,5-2 millones de casos nuevos al a\u00f1o. Hoy en d\u00eda la asociaci\u00f3n de lishmaniasis visceral con el sida se considera una enfermedad emergente. Teniendo en cuenta que no existe ninguna terapia totalmente efectiva frente a  la infecci\u00f3n, que los f\u00e1rmacos utilizados son muy t\u00f3xicos y la aparici\u00f3n de resistencias a ellos por parte del par\u00e1sito, hace necesario buscar nuevas estrategias para combatir la enfermedad.  en general, los protozoos par\u00e1sitos son organismos altamente sensibles la estr\u00e9s oxidativo. Bien porque su h\u00e1bitat es pobre en ox\u00edgeno o porque en alg\u00fan caso carecen de alguna de las enzimas que metabolizan su h\u00e1bitat es pobre en ox\u00edgeno o porque en alg\u00fan caso carecen de alguna de las enzimas que metabolizan radicales libres, por ejemplo leishmania no posee catalasa, son susceptibles a la acci\u00f3n de especies reactivas del ox\u00edgeno.  durante la fase en el interior de la c\u00e9lula hu\u00e9sped, leishmania est\u00e1 expuesta a la acci\u00f3n de diversos radicales libres como per\u00f3xido de hidr\u00f3geno (h2o2), ani\u00f3n super\u00f3xido (o2) y \u00f3xido n\u00edrico (no), que son liberados por el macr\u00f3fago durante la fagocitosis como mecanismo de defensa del hu\u00e9sped contra el par\u00e1sito.  a pesar de ello, leishamnia es capaz de sobrevivir en el interior del macr\u00f3fago, evolucionar hasta la forma mastigote, multiplicarse y seguir infectando a nuevos c\u00e9lulas. En estas situaciones de estr\u00e9s oxidativo, el par\u00e1sito debe desarrollar mecanismos de defensa antioxidante.  son numerosos los da\u00f1os que se producen en el organismo pat\u00f3geno. La oxidaci\u00f3n de l\u00edpidos y la desnaturalizaci\u00f3n de prote\u00ednas se podr\u00edan considerar da\u00f1os secundarios pues estas macr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n molecular de la reparaci\u00f3n de sitios ab\u00e1sicos en el dna de leishmania major<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n molecular de la reparaci\u00f3n de sitios ab\u00e1sicos en el dna de leishmania major <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Claribel Gallego Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Ruiz P\u00e9rez Luis Miguel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan a (secretario) P\u00e9rez torres <\/li>\n<li>Jos\u00e9 Mu\u00f1oz dorado (vocal)<\/li>\n<li> Del rio legazpi alfonso (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Claribel Gallego Garc\u00eda El protozzo par\u00e1sito leishmania major es el agente causal de una de las enfermedades [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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