{"id":144498,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-diferentes-antiulcerosos-sobre-la-cinetica-y-los-efectos-de-la-metadona-oral\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"influencia-de-diferentes-antiulcerosos-sobre-la-cinetica-y-los-efectos-de-la-metadona-oral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-de-diferentes-antiulcerosos-sobre-la-cinetica-y-los-efectos-de-la-metadona-oral\/","title":{"rendered":"Influencia de diferentes antiulcerosos sobre la cinetica y los efectos de la metadona oral"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Castro De Cabo Juli\u00e1n De <\/strong><\/h2>\n<p>En este trabajo se ha estudiado, en un modelo animal (ratas), la influencia que sobre la cinetica y los efectos farmacologicos (analgesia y depresion respiratoria) de la metadona, tiene la administracion de diversos antiulcerosos (sucralfato, omeprazol) y la modificacion del ph gastrico. Se emplearon 120 ratas (sprague dawley), divididas en 6 grupos de 20, para el estudio de la depresion respiratoria. A cada uno de los grupos se le administro una disolucion de metadona oral (5 mg\/kg) junto con una cantidad fija de agua, tampon ph2, tampon ph 7,2, disolucion de bicarbonato, disolucion de sucralfato (50 mg\/ml) o administracion previa i.V. De omeprazol. (2mg\/kg). Mediante un pneumotacometro se registro la frecuencia y amplitud respiratoria, midiendose a la vez la gasometria sanguinea. En los mismos grupos de animales se realizo el estudio de analgesia (2 mg\/kg, de metadona oral) mediante la tecnica de tail-flick. Paralelamente, se determinaron las concentraciones de metadona a diversos tiempos tras su administracion.  como conclusiones del estudio se puede afirmar que la absorcion de la metadona aumento a medida que aumento el ph del tracto gastrointestinal, habiendo correlacion entre el ph y la cantidad total absorbida (abc0-180). Los efectos farmacologicos de la metadona (depresion respiratoria y grado de analgesia) aumentaron tambien a medida que lo hizo el ph gastrico, existiendo correlacion entre ambos. El sucralfato produjo un retraso en la absorcion de la metadona, y como consecuencia de ello un retraso en la manifestacion de los efectos farmacologicos. Por otra parte, con omeprazol el abc0-180 de metadona y sus efectos farmacologicos son mayores de lo que cabria esperar, considerando unicamente la modificacion del ph gastrico provocada por el omeprazol.  este efecto se puede explicar teniendo en cuenta el posible efecto inhibidor del omeprazol sobre el citocromo p450, el cual interviene en el metabolismo de la metadona.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de diferentes antiulcerosos sobre la cinetica y los efectos de la metadona oral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de diferentes antiulcerosos sobre la cinetica y los efectos de la metadona oral <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Castro De Cabo Juli\u00e1n De <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodriguez Sasiain Jos\u00e9 Miguel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Felix Mar\u00eda Go\u00f1i Urcelay <\/li>\n<li>Manuel Baeyens Jose (vocal)<\/li>\n<li>Margarita Arboix Arbo (vocal)<\/li>\n<li>David D\u00edez Mart\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Castro De Cabo Juli\u00e1n De En este trabajo se ha estudiado, en un modelo animal (ratas), la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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