{"id":144540,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificaciones-en-la-cinetica-y-en-el-efecto-del-propranolol-inducidas-por-la-administracion-concomitante-de-vitamina-c\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"modificaciones-en-la-cinetica-y-en-el-efecto-del-propranolol-inducidas-por-la-administracion-concomitante-de-vitamina-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modificaciones-en-la-cinetica-y-en-el-efecto-del-propranolol-inducidas-por-la-administracion-concomitante-de-vitamina-c\/","title":{"rendered":"Modificaciones en la cinetica y en el efecto del propranolol inducidas por la administracion concomitante de vitamina c."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonzalez Echebarria Jon Peli <\/strong><\/h2>\n<p>La administracion de dos gramos de vitamina c al grupo de voluntarios sanos elegido, constituido por jovenes de ambos sexos con edades similares, ha modificado tanto la cinetica oral del propranolol, a traves de las areas bajo la curva, concentraciones maximas alcanzadas y tiempo en alcanzar dicha concentracion maxima de las tres sustancias analizadas: propranolol total (propranolol libre+propranolol conjugado con acido glucuronico), propranolol libre (no metabolizado ni conjugado, no confundir con fraccion no fijada a proteinas plasmaticas) y 4-hidroxi-propranolol (unico metabolito activo). Ademas de la cinetica del propranolol la administracion de dos gramos de vitamina c treinta minutos antes de la de propranolol modifico el efecto del propranolol sobre el qtc (indice de bradicardia) disminuyendolo, hecho que tambien se apoya en los resultados cineticos, ya que las areas de propranolol libre (el unico activo) eran menores tras la administracion de vitamina c que en ayunas para todos los individuos que entraron en el estudio. Por ultimo con el fin de conocer los parametros cineticos del propranolol, sobre todo su biodisponibilidad se realizo una administracion por via intravenosa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaciones en la cinetica y en el efecto del propranolol inducidas por la administracion concomitante de vitamina c.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaciones en la cinetica y en el efecto del propranolol inducidas por la administracion concomitante de vitamina c. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonzalez Echebarria Jon Peli <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodriguez Sasiain Jos\u00e9 Miguel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alfonso Moreno Gonzalez <\/li>\n<li>Antonio Quintana Loyola (vocal)<\/li>\n<li> Morcillo Sanchez Esteban Jes\u00fas (vocal)<\/li>\n<li>Alfonso Carvajal Garcia-pando (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalez Echebarria Jon Peli La administracion de dos gramos de vitamina c al grupo de voluntarios sanos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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