{"id":144557,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracteristicas-farmacocineticas-de-la-tobramicina\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"caracteristicas-farmacocineticas-de-la-tobramicina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracteristicas-farmacocineticas-de-la-tobramicina\/","title":{"rendered":"Caracteristicas farmacocineticas de la tobramicina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gabriel Inclan Iribar <\/strong><\/h2>\n<p>Hoy se establece que el ajuste individual de la dosis de un farmaco en base a los niveles de este en plasma puede prevenir o minimizar sus efectos adversos. Para ello se tiende a la monitorizacion de dichos niveles aunque, es necesario que el farmaco reuna una serie de caracteristicas tales como la existencia de un margen terapeutico estrecho y bien definido que se cumpla la relacion entre los niveles plasmaticos y efectos terapeuticos o toxicos y que la medida de los efectos no sea facilmente realizable. Los antibioticos aminoglucosidos cumplen estos requisitos, sin embargo la medicion de niveles plasmaticos es muy costosa en tiempo y cuantia economica por lo que, se han desarrollado programas para predecir con las minimas determinaciones analiticas y dosis acordes con su margen terapeutico. Sin embargo aun no existe un consenso actual sobre cual de los metodos es el mas adecuado para instaurar un regimen posologico correcto con aminoglucosidos. En este estudio se ha intentado profundizar en el conocimiento de las caracteristicas farmacocineticas de la tobramicina en pacientes hospitalizados; determinar los parametros farmacocineticos de dicha poblacion y analizar los factores que intervienen intra e interindividualmente; analizar la capacidad predictiva de varios metodos algoritmicos y bayesianos (koup, abbott, pkdosing) respecto a datos reales estimar el riesgo potencial del regimen de dosificacion empleado y extraer un monograma sencillo de dosificacion.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracteristicas farmacocineticas de la tobramicina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracteristicas farmacocineticas de la tobramicina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gabriel Inclan Iribar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosario Calvo Duo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Felipe Miguel De La Villa <\/li>\n<li> Gonzalez De Zarate Pedro (vocal)<\/li>\n<li>Jes\u00fas Gonzalez  Macias (vocal)<\/li>\n<li>Ignacio Alberola Gomez-escobar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gabriel Inclan Iribar Hoy se establece que el ajuste individual de la dosis de un farmaco en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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