{"id":14466,"date":"2018-03-09T09:01:10","date_gmt":"2018-03-09T09:01:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-enfoques-inmunologicos-en-el-diagnostico-y-patogenia-de-la-enfermedad-cela%c2%adaca-y-otras-enteropata%c2%adas\/"},"modified":"2018-03-09T09:01:10","modified_gmt":"2018-03-09T09:01:10","slug":"nuevos-enfoques-inmunologicos-en-el-diagnostico-y-patogenia-de-la-enfermedad-cela%c2%adaca-y-otras-enteropata%c2%adas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nuevos-enfoques-inmunologicos-en-el-diagnostico-y-patogenia-de-la-enfermedad-cela%c2%adaca-y-otras-enteropata%c2%adas\/","title":{"rendered":"Nuevos enfoques inmunol\u00f3gicos en el diagn\u00f3stico y patogenia de la enfermedad cel\u00edaca y otras enteropat\u00edas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Le\u00f3n Prieto <\/strong><\/h2>\n<p>La enfermedad cel\u00edaca (ec) es una enteropat\u00eda cr\u00f3nica de patogenia inmunol\u00f3gica, muy prevalente pero a\u00fan infradiagnosticada, lo que aumenta el riesgo de aparici\u00f3n de complicaciones. El presente trabajo se centra en tres \u00e1reas de la ec.  en primer lugar, en el diagn\u00f3stico de cribaje y sospecha de la ec, mediante el desarrollo de una t\u00e9cnica de elisa de transglutaminasa tisular (ttg) y la comparaci\u00f3n de distintas fuentes antig\u00e9nicas de ttg para elisa, validando la utilidad de esta t\u00e9cnica frente a la t\u00e9cnica de inmunofluorescencia indirecta convencional (determinaci\u00f3n de anticuerpos anti-endomisio). Se demuestra, mediante la realizaci\u00f3n de western blot, la inespecificidad de ciertas reactividades encontradas en los elisa, principalmente en pacientes diab\u00e9ticos, y que resultaron debidas a la baja pureza del ant\u00edgeno de ttg m\u00e1s extendido y com\u00fanmente utilizado, el obtenido de extracto de h\u00edgado de cobaya.  en segundo lugar, este trabajo incide en el diagn\u00f3stico de confirmaci\u00f3n de la ec. Se describen las alteraciones en las subpoblaciones de linfocitos intraepiteliales intestinales (lie) que caracterizan a las distintas fases de la ec, tanto en ni\u00f1os como en adultos, demostrando que su estudio, por citometr\u00eda de flujo, permite el diagn\u00f3stico diferencial de la ec respecto a otras enteropat\u00edas y enfermedades digestivas, disminuyendo la necesidad de pruebas invasivas.  en tercer lugar, se profundiza en la patogenia de la ec. Para ello, se caracterizan funcionalmente los lie nk-like, que desaparecen en esta enfermedad, constat\u00e1ndose su capacidad citol\u00edtica (pueden considerarse nk bona fide), su reaparici\u00f3n en algunos pacientes tratados, y la existencia de un subtipo con cd3e citopl\u00e1smico. Finalmente, se estudia la capacidad de producci\u00f3n de citocinas por las subpoblaciones de lie en la ec y en controles, observ\u00e1ndose (por fluorocitometr\u00eda y rt-pcr) un patr\u00f3n tipo 1 en lie alfa beta, lie gamma * y lie nk-like, s<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos enfoques inmunol\u00f3gicos en el diagn\u00f3stico y patogenia de la enfermedad cel\u00edaca y otras enteropat\u00edas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos enfoques inmunol\u00f3gicos en el diagn\u00f3stico y patogenia de la enfermedad cel\u00edaca y otras enteropat\u00edas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Le\u00f3n Prieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Garbi\u00f1e Roy Ari\u00f1o<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: roberto Marco cuellar <\/li>\n<li>Jos\u00e9 Manuel Martin villa (vocal)<\/li>\n<li>gumersindo Fontan casariego (vocal)<\/li>\n<li>pedro Gonz\u00e1lez porqu\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Le\u00f3n Prieto La enfermedad cel\u00edaca (ec) es una enteropat\u00eda cr\u00f3nica de patogenia inmunol\u00f3gica, muy prevalente pero [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[4229,160,2148,35,9,491,1737,2612,139,17],"tags":[46560,23348,6331,23123,46561,29645],"class_list":["post-14466","post","type-post","status-publish","format-standard","hentry","category-anticuerpos-de-tejidos","category-bioquimica","category-bioquimica-inmunologica","category-ciencias-de-la-vida","category-ciencias-medicas","category-gastroenterologia","category-inmunologia","category-inmunoquimica","category-medicina-interna","category-quimica","tag-francisco-leon-prieto","tag-garbine-roy-arino","tag-gumersindo-fontan-casariego","tag-jose-manuel-martin-villa","tag-pedro-gonzalez-porque","tag-roberto-marco-cuellar"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14466","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=14466"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14466\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=14466"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=14466"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=14466"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}