{"id":144715,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-al-estudio-clinico-de-los-efectos-no-cardiovasculares-de-los-antagonistas-del-calcio\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"contribucion-al-estudio-clinico-de-los-efectos-no-cardiovasculares-de-los-antagonistas-del-calcio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/contribucion-al-estudio-clinico-de-los-efectos-no-cardiovasculares-de-los-antagonistas-del-calcio\/","title":{"rendered":"Contribucion al estudio clinico de los efectos no cardiovasculares de los antagonistas del calcio"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Bigorra Llosas <\/strong><\/h2>\n<p>La investigacion y desarrollo de medicamentos, especialmente su desarrollo clinico ha adquirido una creciente complejidad en los ultimos a\u00f1os. Los antagonistas del calcio son un grupo heterogeneo de sustancias que comparten la propiedad de inhibir la entrada de calcio en la celula. De ellas, la familia mas extensa es la de los derivados de la 1,4-dihidropiridina.  en el presente estudio se evaluaron algunos efectos no cardiovasculares de los antagonistas del calcio dihidropiridinicos: nisoldipino, nitrendipino y nimodipino.  se demostro que nisoldipino, farmaco desarrollado para el tratamiento de la angina de pecho y la hipertension arterial aumentaba la natriuresis asi como la capacidad renal para excretar una sobrecarga intravenosa de sodio tanto en voluntarios normotensos como en pacientes hipertensos esenciales.  aunque se conocia que el medicamento antihipertensivo nitrendipino aumentaba la natriuresis de forma aguda, los resultados a largo plazo en pacientes hipertensos eran contradictorios. Mediante la administracion de suero salino intravenoso se comprobo que el incremento de la capacidad renal para excretar sodio persistia tras 6 meses de tratamiento.  nimodipino muestra una actividad preferencial a nivel cerebrovascular, en este ensayo a doble ciego controlado con placebo se observo que este farmaco podria mejorar la evolucion neurologica en un subgrupo de pacientes con infarto isquemico cerebral agudo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribucion al estudio clinico de los efectos no cardiovasculares de los antagonistas del calcio<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribucion al estudio clinico de los efectos no cardiovasculares de los antagonistas del calcio <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Bigorra Llosas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francesc Jan\u00e9 Carrenca<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Salva Miquel <\/li>\n<li>M. Eulalia Planas  Domingo (vocal)<\/li>\n<li>Jordi Cami Morell (vocal)<\/li>\n<li>Eduardo Mart\u00ednez Vila (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Bigorra Llosas La investigacion y desarrollo de medicamentos, especialmente su desarrollo clinico ha adquirido una creciente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,189,957,483],"tags":[18156,51,13665,297,259517,13850],"class_list":["post-144715","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacodinamia","category-farmacologia","category-mecanismos-de-accion-de-los-farmacos","tag-eduardo-Martinez-vila","tag-francesc-jane-carrenca","tag-jordi-cami-morell","tag-jose-antonio-salva-miquel","tag-juan-bigorra-llosas","tag-m-eulalia-planas-domingo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/144715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=144715"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/144715\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=144715"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=144715"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=144715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}