{"id":144716,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribuciones-al-estudio-de-la-inmunidad-celular-en-la-diabetes-mellitus-tipo-i-insulinodependiente\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"contribuciones-al-estudio-de-la-inmunidad-celular-en-la-diabetes-mellitus-tipo-i-insulinodependiente","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/contribuciones-al-estudio-de-la-inmunidad-celular-en-la-diabetes-mellitus-tipo-i-insulinodependiente\/","title":{"rendered":"Contribuciones al estudio de la inmunidad celular en la diabetes mellitus tipo i, insulinodependiente"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jaume Binimelis Vidal <\/strong><\/h2>\n<p>En pacientes afectos de diabetes mellitus tipo 1, insulino dependiente, recientemente diagnosticada (dmid) y en individuos no diabeticos con positividad para ica, se estudian: 1) la existencia de alteraciones fenotipicas en los linfocitos t, y el porcentaje de linfocitos t activados circulantes (citometria de flujo), asi como sus fenotipos. 2) la relacion entre activacion linfocitaria y: a) reserva pancreatica; b) respuesta a la glucosa endovenosa y valor pronostico en cuanto a futuro desarrollo de dmid. 3) la respuesta proliferativa a celulas beta (rin m5f) de celulas mononucleares de sangre periferica. 4) expandir, clonar y caracterizar linfocitos procedentes de biopsias de alotransplantes pancreaticos.  resultados: no se observan alteraciones en las subpoblaciones cd3, cd4 y cd8. Un 35% de los pacientes afectos de dmid y un 50% de los individuos no diabeticos ica positivos presentan un exceso de linfocitos t activados circulantes. Existe una relacion inversa entre reserva pancreatica y activacion linfocitaria. El exceso de linfocitos t activados circulantes carece de valor pronostico en cuanto al futuro desarrollo de dmid, y no se asocia a alteraciones precoces de la funcion insulinosecretora en individuos a riesgo de desarrollar dmid. Observamos un efecto inhibidor de la proliferacion linfocitaria en las celulas rin m5f sonicadas. Este efecto se observa solo en su fraccion soluble, por lo que esta fue descartada en estudios posteriores. 6 de 9 pacientes afectos de dmid estudiados presentaron respuesta proliferativa especifica frente a las celulas rin m5f. A partir de fragmentos de tejido pancreatico alotransplantado en fase de rechazo se obtuvieron 40&#215;10 6 linfocitos t, la mayoria cd8+., Y 15 clonas. Se observa actividad citotoxica de los tipos \u00abnatural killer\u00bb, \u00abdependiente de lectinas\u00bb y \u00abactivada por linfocinas\u00bb frecuentemente, y en algunas clonas se observan actividades proliferativa y\/o citotoxica especifica, asi como pr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribuciones al estudio de la inmunidad celular en la diabetes mellitus tipo i, insulinodependiente<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribuciones al estudio de la inmunidad celular en la diabetes mellitus tipo i, insulinodependiente <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jaume Binimelis Vidal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Leiva Hidalgo Alberto De<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francesc Gonz\u00e1lez Sastre <\/li>\n<li>Ramon Gomis De Barbar? (vocal)<\/li>\n<li> Rodriguez Sanchez Jos\u00e9 Luis (vocal)<\/li>\n<li>Jos\u00e9 Rodriguez Espinosa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jaume Binimelis Vidal En pacientes afectos de diabetes mellitus tipo 1, insulino dependiente, recientemente diagnosticada (dmid) y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,851,1737,139],"tags":[13646,259518,29501,13645,1375,38682],"class_list":["post-144716","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-endocrinologia","category-inmunologia","category-medicina-interna","tag-francesc-gonzalez-sastre","tag-jaume-binimelis-vidal","tag-jose-rodriguez-espinosa","tag-leiva-hidalgo-alberto-de","tag-ramon-gomis-de-barbar","tag-rodriguez-sanchez-jose-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/144716","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=144716"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/144716\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=144716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=144716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=144716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}