{"id":144800,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-respuesta-inmunologica-contra-el-antigeno-neuronal-hu-expresado-en-el-tumor-de-los-pacientes-con-encefalomielitis-y-o-neuronopatia-sensitiva-paraneoplasica\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"estudio-de-la-respuesta-inmunologica-contra-el-antigeno-neuronal-hu-expresado-en-el-tumor-de-los-pacientes-con-encefalomielitis-y-o-neuronopatia-sensitiva-paraneoplasica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-respuesta-inmunologica-contra-el-antigeno-neuronal-hu-expresado-en-el-tumor-de-los-pacientes-con-encefalomielitis-y-o-neuronopatia-sensitiva-paraneoplasica\/","title":{"rendered":"Estudio de la respuesta inmunologica contra el antigeno neuronal hu expresado en el tumor de los pacientes con encefalomielitis y\/o neuronopatia sensitiva paraneoplasica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Josep Dalmau Obrador <\/strong><\/h2>\n<p>Se ha estudiado la clinica y biolog\u00eda de la respuesta inmunologica contra el antigeno neuronal hu expresado en el tumor de los pacientes con encefalopatia y\/o neuronopatia sensitiva paraneoplasicas (emp\/nsp) y en el cancer de pulmon de celulas peque\u00f1as (cpcp). Para ello se han utilizado metodos de investigacion clinica, histopatolog\u00eda y tecnicas de laboratorio que van desde inmunohistoquimica y western blotting a estudios de genetica molecular. Ello ha permitido 1) definir mejor un sindrome neurologico infrecuente pero infradiagnosticado (emp\/nsp), 2) identificar un modelo excepcional de respuesta inmunologica antitumoral, mediante el cual la expresion de determinadas proteinas tumorales desencadena una respuesta inmunologica contra la neoplasia que se maldirije contra proteinas similares expresadas en el sistema nervioso; y 3) caracterizar a nivel molecular una nueva iproteina especifica neuronal (hud) que parece tener un papel crucial en el establecimiento y mantenimiento del fenotipo de las neuronas y en el desarrollo del sistema nervioso de los vertebrados. Por otra parte los estudios de laboratorio y genetica molecular de hud se han aplicado de manera inmediata a la clinica, y han proporcionado 1) un metodo diagnostico altamente especifico del caracter paraneoplasico de determinados sintomas clinicos, que permite ademas dirigir la busqueda de la neoplasia a uno (pulmon) o pocos organos, y 2) un valioso metodo para identificar determinados tipos histologicos de tumores, particularmente cpcp.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la respuesta inmunologica contra el antigeno neuronal hu expresado en el tumor de los pacientes con encefalomielitis y\/o neuronopatia sensitiva paraneoplasica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la respuesta inmunologica contra el antigeno neuronal hu expresado en el tumor de los pacientes con encefalomielitis y\/o neuronopatia sensitiva paraneoplasica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Josep Dalmau Obrador <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Grau Veciana Jos\u00e9 M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Marti-vilalta Jose <\/li>\n<li>Francesc Graus  Ribas (vocal)<\/li>\n<li>Isidro Ferrer Abizanda (vocal)<\/li>\n<li>Carlos Roig Arnall (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Josep Dalmau Obrador Se ha estudiado la clinica y biolog\u00eda de la respuesta inmunologica contra el antigeno [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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