{"id":144817,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-insulina-y-el-igf-1-en-la-fisiopatologia-del-sopq\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"papel-de-la-insulina-y-el-igf-1-en-la-fisiopatologia-del-sopq","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-la-insulina-y-el-igf-1-en-la-fisiopatologia-del-sopq\/","title":{"rendered":"Papel de la insulina y el igf 1 en la fisiopatolog\u00eda del sopq"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Jos\u00e9 Espin\u00f3s G\u00f3mez <\/strong><\/h2>\n<p>La relacion entre el hiperinsulinismo y el hiperandrogenismo ovarico es controvertida. El estudio del papel de la insulina y\/o el igf 1 en la fisiopatolog\u00eda del sopq no ha dado resultados concluyentes.  objetivo. Evidenciar si el sopq se asocia a insulinoresistencia (ir).  determinar si el aumento endogeno de insulina y\/o igf1 se asocia a un incremento paralelo de los androgenos, una disminucion de la shbg o un patron especifico de secrecion de gonadotrofinas. Valorar su influencia en la esteroidogenesis suprarrenal.  material y metodos: se estudiaron 14 pacientes con criterios clinicos, analiticos y ecograficos de sopq. El grupo control (n-9) lo constituian mujeres con ciclos menstruales normales sin evidencia de hiperandrogenismo.  en situacion basal y tras la ingesta de 100 g de glucosa se determinaron en sangre periferica las concentraciones de insulina (i), igf 1, glucosa, testosterona (t), itl, shbg, androstonodiona, 170 hprogesterona, cortisol, sdha, fsh, lh y progesterona. Se analizaron los sitios de union y la afinidad a la insulina en hematies.  resultados: se aprecio una correlacion positiva entre el imc y el cociente abdomen\/cadera con las concentraciones basales de i,i\/g y t. El area bajo la curva de i se asocio positivamente con el de t y negativamente con el de shbg.  se pudieron establecer 2 grupos de pacientes en relacion a las concentraciones basales de i y lh. No se aprecio relacion entre la i y\/o el igf 1 con las gonadotrofinas y los esteroides suprarrenales.  conclusiones: un alto % de pacientes con sopq presentan hiporinsulinismo reflejo de una ir atribuible a una disminucion en el numero y\/o afinidad del receptor. La obesidad superior se asocia a ir. Existe una correlacion negativa entre las concentraciones de i y lh. El hiperinsulinismo agudo no induce a corto plazo modificaciones en las concentraciones plasmaticas de androgenos. La relacion entre la i y la shbg podria constituir un mecanismo coad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la insulina y el igf 1 en la fisiopatolog\u00eda del sopq<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la insulina y el igf 1 en la fisiopatolog\u00eda del sopq <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Jos\u00e9 Espin\u00f3s G\u00f3mez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquim Calaf Alsina<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Joan Esteban Altirriba <\/li>\n<li>Jos\u00e9 Rodriguez Espinosa (vocal)<\/li>\n<li>Enric Vilardell Latorre (vocal)<\/li>\n<li>Roser Casamitjana Abella (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Jos\u00e9 Espin\u00f3s G\u00f3mez La relacion entre el hiperinsulinismo y el hiperandrogenismo ovarico es controvertida. El estudio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,135],"tags":[2134,115749,29326,29501,191056,1373],"class_list":["post-144817","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-ginecologia","tag-enric-vilardell-latorre","tag-joan-esteban-altirriba","tag-joaquim-calaf-alsina","tag-jose-rodriguez-espinosa","tag-juan-jose-espinos-gomez","tag-roser-casamitjana-abella"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/144817","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=144817"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/144817\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=144817"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=144817"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=144817"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}