{"id":144848,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-presencia-del-virus-papiloma-humano-en-lesiones-proliferativas-de-la-mucosa-oral-mediante-hibridacion-in-situ-y-reaccion-en-cadena-de-polimerasa\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"estudio-de-la-presencia-del-virus-papiloma-humano-en-lesiones-proliferativas-de-la-mucosa-oral-mediante-hibridacion-in-situ-y-reaccion-en-cadena-de-polimerasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-presencia-del-virus-papiloma-humano-en-lesiones-proliferativas-de-la-mucosa-oral-mediante-hibridacion-in-situ-y-reaccion-en-cadena-de-polimerasa\/","title":{"rendered":"Estudio de la presencia del virus papiloma humano en lesiones proliferativas de la mucosa oral mediante hibridacion in situ y reaccion en cadena de polimerasa."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Muret M. Pilar <\/strong><\/h2>\n<p>Objetivos: 1. Detectar mediante hibridacion in situ (his) la presencia de pvh 6\/11, 16\/18, 31\/33\/51 en mucosa oral.  2. Detectar mediante reaccion en cadena de polimerasa (pcr) la presencia de pvh 16 en mucosa oral. 3. Estudiar los signos sugestivos de infeccion por pvh en mucosa oral. 4. Estudiar la presencia de la proteina p53 mediante inmunohistoquimica, su relacion con los signos histologicos sugestivos de infeccion por pvh, y su relacion con la clinica. 5. Estudiar los factores clinicos asociados al desarrollo de carcinoma escamoso de la mucosa oral.  metodos: 95 muestras en parafina de mucosa oral agrupadas segun diagnostico histologico en leucoqueratosis, leucoplasia, careinoma escamoso, hiperplasia epitelial y mucosa normal. Se utilizo la his y la pcr para la deteccion de pvh, un examen histologico al microscopio optico, la inmunohistoquimica para la deteccion de la proteina p53, revision de las historias clinicas y analisis estadistico para los factores clinicos y epidemiologicos asociados al desarrollo de carcinoma oral.  resultados: no se detecto en ninguna de las 95 muestras la presencia de pvh de los tipos investigados, ni por his, ni por pcr. Se observaron signos histologicos de infeccion por pvh en 19 de 85 muestras. La p53 se detecto en el 33% de ca. Escamosos, y en un porcentaje similar de muestras con o sin signos histologicos de infeccion por pvh, y de forma predominante en fumadores y con habito laboral con exposicion solar. Fueron significativos estadisticamente el sexo varon, la edad avanzada, el habito tabaquico y el habito enolico para el desarrollo de ca. Escamoso de la mucosa oral.  conclusiones: 1. No se ha detectado la presencia de pvh 6\/11, 16\/18, 31\/33\/51 mediante his, ni del pvh 16 mediante pcr en las 95 muestra de mucosa oral analizadas.  no se le puede atribuir un papel oncogenico al pvh 16 en la mucosa oral por extrapolacion de lo que ocurre en la mucosa genital femenina. 2. Los signos de inf<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la presencia del virus papiloma humano en lesiones proliferativas de la mucosa oral mediante hibridacion in situ y reaccion en cadena de polimerasa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la presencia del virus papiloma humano en lesiones proliferativas de la mucosa oral mediante hibridacion in situ y reaccion en cadena de polimerasa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Muret M. Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Moragas Vi\u00f1as<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 M Mascaro Ballester <\/li>\n<li>Carlos Ferr\u00e1ndiz Foraster (vocal)<\/li>\n<li>Antoni Castells Rodellas (vocal)<\/li>\n<li>Josep Antoni Bomb\u00ed Latorre (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Muret M. Pilar Objetivos: 1. Detectar mediante hibridacion in situ (his) la presencia de pvh 6\/11, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,97,1085,139],"tags":[217,158,259683,1237,115726,14013],"class_list":["post-144848","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-dermatologia","category-enfermedades-infecciosas","category-medicina-interna","tag-antoni-castells-rodellas","tag-carlos-ferrandiz-foraster","tag-garcia-muret-m-pilar","tag-jose-m-mascaro-ballester","tag-jose-moragas-vinas","tag-josep-antoni-bombi-latorre"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/144848","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=144848"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/144848\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=144848"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=144848"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=144848"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}