{"id":144856,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/eficacia-de-la-administracion-de-gentamicina-una-vez-al-dia-en-el-tratamiento-de-la-endocarditis-experimental-por-estreptococos-del-grupo-viridans\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"eficacia-de-la-administracion-de-gentamicina-una-vez-al-dia-en-el-tratamiento-de-la-endocarditis-experimental-por-estreptococos-del-grupo-viridans","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/eficacia-de-la-administracion-de-gentamicina-una-vez-al-dia-en-el-tratamiento-de-la-endocarditis-experimental-por-estreptococos-del-grupo-viridans\/","title":{"rendered":"Eficacia de la administracion de gentamicina una vez al dia en el tratamiento de la endocarditis experimental por estreptococos del grupo viridans."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joan Gavalda Santapau <\/strong><\/h2>\n<p>Objetivos: la administracion de gentamicina (g) en dosis unica diaria (dud) simplificaria el tratamiento de la endocarditis producida por estreptococos viridans (ev) en humanos. Se estudia la eficacia de penicilina g procaina (pp) 1.2 m u\/8h im, sola o en combinacion con diferentes dosis y regimenes de g en el tto de la endocarditis experimental (ee) por ev penicilin-sensible (ps),-tolerante (pt) y -moderado (pr) o altamente resistente (pr) en conejos.  metodos: se realizaron cmi\/cmb con la tecnica de macrodilucion en caldo. La farmacocinetica de pp se obtuvo mediante bioensayo y la de gentamicina mediante inmunofluorescencia de polarizacion. La endocarditis trombotica no bacteriana (etnb) se establecio por el metodo de garrison y freedman. Los conejos fueron infectados con 105 de ufc de ev\/ml iv a las 24 h de producirse la etnb, para las cepas evps, evpt y evpn y con 106 ufc\/ml para la cepa evpr. El tratamiento se inicio 48 h despues de producirse la infeccion. Al 3er dia de tto los animales fueron sacrificados y las vegetaciones cultivadas cuantitativamente. Los resultados se expresaron como media+-ds de log10 ufc\/g de vegetacion y analizado por analisis de la suma de rangos (test de wilcoxon).  resultados: la cmi\/cmb(ug\/ml) de p y g fue:  ps&lt;0,03\/&lt;0,03-8\/16;pt&lt;0,03\/ 32-8\/16;pr 0,5\/8-16; pr2\/2-8\/16.Pp + g mostraron sinergia antibiotica ante las 3 cepas de ev.G se administro im en dud de 3 mg\/kg\/24h o 1 mg\/kg\/24h vs 3 dosis divididas de 1 mg\/kg. Las concentraciones sericas medias (ug\/ml) a 0,5h\/24h fueron: g 3mg\/kg:8,53\/-;g1 mg\/kg: 3,85\/-; pp:25,6\/&lt;0,5.  conclusiones: 1- para las tres cepas todos los tratamientos disminuyeron significativamente el n de ufc respecto a los animales control sin tto (p&lt;0.05). 2- para evps g a dud de 1 mg\/kg no mejoro la eficacia de p sola(p 0.05). 3-las pautas de pp con g 1 mg\/kg\/8h o g 3 mg\/kg dud fueron mas efectivas (p&lt;0.05) que pp sola o asociada a g 1 mg\/kg dud. 4- indepe<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Eficacia de la administracion de gentamicina una vez al dia en el tratamiento de la endocarditis experimental por estreptococos del grupo viridans.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Eficacia de la administracion de gentamicina una vez al dia en el tratamiento de la endocarditis experimental por estreptococos del grupo viridans. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joan Gavalda Santapau <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Manuel Martinez Vazquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Sim\u00f3 Schwartz Riera <\/li>\n<li>Francisco Gudiol Munne (vocal)<\/li>\n<li>Emilio Bouza Santiago (vocal)<\/li>\n<li>Francisco Jos\u00e9 Fern\u00e1ndez P\u00e9rez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joan Gavalda Santapau Objetivos: la administracion de gentamicina (g) en dosis unica diaria (dud) simplificaria el tratamiento 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