{"id":14487,"date":"2018-03-09T09:01:12","date_gmt":"2018-03-09T09:01:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/prediccion-de-la-invasion-ganglionar-de-la-axila-a-partir-de-factores-pronosticos-moleculares-del-tumor-primario-en-cancer-de-mama-pt1\/"},"modified":"2018-03-09T09:01:12","modified_gmt":"2018-03-09T09:01:12","slug":"prediccion-de-la-invasion-ganglionar-de-la-axila-a-partir-de-factores-pronosticos-moleculares-del-tumor-primario-en-cancer-de-mama-pt1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/prediccion-de-la-invasion-ganglionar-de-la-axila-a-partir-de-factores-pronosticos-moleculares-del-tumor-primario-en-cancer-de-mama-pt1\/","title":{"rendered":"Prediccion de la invasi\u00f3n ganglionar de la axila a partir de factores pron\u00f3sticos moleculares del tumor primario en c\u00e1ncer de mama pt1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Tejerina G\u00f3mez <\/strong><\/h2>\n<p>Las pacientes de c\u00e1ncer de mama, cuando fallecen a causa de su c\u00e1ncer a causa del tumor primario, sino a causa de las met\u00e1stasis que \u00e9ste pueda originar. El primer paso en la cadena metast\u00e1tica pr\u00e1cticamente siempre es la invasi\u00f3n ganglionar de la axila. Por tanto, es fundamental conocer que factores biol\u00f3gicos son aquellos que van a determinar si un tumor va a producir met\u00e1stasis o no, ya en los estadios iniciales de su desarrollo.  en el presente trabajo se analizaron 229 tumores de mama en estadio quir\u00fargico t1. Se incluyeron tumores de cualquier variante histol\u00f3gica, con la condici\u00f3n de que presentaran un \u00fanico foco tumoral. Las pacientes no deb\u00edan haber recibido ning\u00fan tratamiento previo, y en la pieza operatoria deb\u00edan haber sido identificados al menos 10 ganglios axiliares.  como factores pron\u00f3sticos de primera generaci\u00f3n se estudiaron en dichos tumores los siguientes: tama\u00f1o, variedad histol\u00f3gica, grado histol\u00f3gico, grado nuclear y la presencia o no de ganglios exiliares invadidos en la pieza operatoria.  como factores pron\u00f3sticos de segunda generaci\u00f3n se estudi\u00f3 la expresi\u00f3n de receptores de estr\u00f3genos y de receptores de progesterona, y finalmente, como factores pron\u00f3sticos de tercera generaci\u00f3n, fueron estudiados la expresi\u00f3n del oncogen c-erbb-2, del gen oncosupresor p53, del ant\u00edgeno de proliferaci\u00f3n ki 67, de cd44std y de complejos upa-pai. Se emple\u00f3 para ello la t\u00e9cnica de la inmunohistoqu\u00edmica y el m\u00e9todo de la estreptavidina-biotinaperoxidasa sobre cortes de parafina.  se analiz\u00f3 la presencia o no de ganglios axilares invadidos en la pieza operatoria en funci\u00f3n de todas las variables pron\u00f3sticas arriba enumeradas.  para el an\u00e1lisis estad\u00edstico de los datos obtenidos, se utiliz\u00f3 en primer lugar un an\u00e1lisis univariante, mediante tests de correlaci\u00f3n no param\u00e9trica, y posteriormente se incluyeron los resultados en un an\u00e1lisis multivariante de regresi\u00f3n log\u00edstica.  en el an<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Prediccion de la invasi\u00f3n ganglionar de la axila a partir de factores pron\u00f3sticos moleculares del tumor primario en c\u00e1ncer de mama pt1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Prediccion de la invasi\u00f3n ganglionar de la axila a partir de factores pron\u00f3sticos moleculares del tumor primario en c\u00e1ncer de mama pt1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Tejerina G\u00f3mez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Rosety Plaza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Gutierrez rodr\u00edguez <\/li>\n<li>Mar\u00eda  del carmen Carrasco molinillo (vocal)<\/li>\n<li>Jos\u00e9 Vazquez tapioles (vocal)<\/li>\n<li>Antonio Ribelles Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Tejerina G\u00f3mez Las pacientes de c\u00e1ncer de mama, cuando fallecen a causa de su c\u00e1ncer a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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