{"id":145003,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-clinica-histologica-e-inmunologica-de-la-reaccion-cutanea-purpurica-minima-inducida-por-inoculacion-de-heparina\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"valoracion-clinica-histologica-e-inmunologica-de-la-reaccion-cutanea-purpurica-minima-inducida-por-inoculacion-de-heparina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valoracion-clinica-histologica-e-inmunologica-de-la-reaccion-cutanea-purpurica-minima-inducida-por-inoculacion-de-heparina\/","title":{"rendered":"Valoracion clinica, histologica e inmunologica de la reaccion cutanea purpurica minima inducida por inoculacion de heparina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ramon Pedragosa Jove <\/strong><\/h2>\n<p>Las lesiones dermatologicas mas significativas provocadas por la heparina son las inflamatorias y las necroticas.  este trabajo hace referencia a un tercer tipo de lesion clinica inducida por la heparina no valorada hasta el momento presente: la lesion purpurica minima en los puntos de inoculacion cutaneos. Esta lesion cutanea es observable en pacientes heparinizados sin ninguna otra manifestacion clinico-alergica llamativa y es reproducible en las pruebas de provocacion dermatologicas (pdp) intradermicas de estos mismos enfermos y de los que presentan lesiones inflamatorias o necroticas inducidas por la heparina. Histologicamente son vasculitis leucocitoclasticas de los peque\u00f1os vasos cutaneos superficiales. Se ha hallado presencia de anticuerpos antiplaquetarios (aap) en todos los casos afectos de reaccion inflamatoria por heparina (6\/6) y en los dos casos afectos de necrosis cutanea, asi como en la mayoria de los pacientes heparinizados que han presentado pdp de tipo purpurico. Los aap detectados en el conjunto de los pacientes estudiados han sido sobre todo de tipo iga.  existe una correlacion entre el tipo de aap y el tipo de anticuerpo hallado en la piel por inmunofluorescencia directa. Los casos que han presentado trombocitopenia, clinicamente mostraban lesiones purpuricas minimas. Mas de la mitad de estos casos han presentado aap del tipo igg fundamentalmente. La evolucion de la trombopenia ha sido reversible y no han aparecido accidentes vasculares como consecuencia de la misma. Finalmente, se ha analizado la influencia de una serie de factores considerados como predisponentes en la presentacion de las lesiones cutaneas heparin-inducidas y de la posibilidad que la heparina se la responsable de las calcifilaxis que presentan algunos pacientes que se hemodializan.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoracion clinica, histologica e inmunologica de la reaccion cutanea purpurica minima inducida por inoculacion de heparina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoracion clinica, histologica e inmunologica de la reaccion cutanea purpurica minima inducida por inoculacion de heparina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ramon Pedragosa Jove <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antoni Castells Rodellas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Manuel Martinez Vazquez <\/li>\n<li>Joan Ferrando Barbera (vocal)<\/li>\n<li> Vidal Rosell M. Teresa (vocal)<\/li>\n<li>Francisco Grimalt Sancho (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ramon Pedragosa Jove Las lesiones dermatologicas mas significativas provocadas por la heparina son las inflamatorias y las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,97],"tags":[217,238994,259869,2869,259868,235567],"class_list":["post-145003","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-dermatologia","tag-antoni-castells-rodellas","tag-francisco-grimalt-sancho","tag-joan-ferrando-barbera","tag-jose-manuel-Martinez-vazquez","tag-ramon-pedragosa-jove","tag-vidal-rosell-m-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145003","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=145003"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145003\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=145003"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=145003"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=145003"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}