{"id":145029,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/activacion-del-complemento-en-el-lupus-eritematoso-sistemico-les\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"activacion-del-complemento-en-el-lupus-eritematoso-sistemico-les","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/activacion-del-complemento-en-el-lupus-eritematoso-sistemico-les\/","title":{"rendered":"Activacion del complemento en el lupus eritematoso sistemico (les)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Manuel Porcel P\u00e9rez <\/strong><\/h2>\n<p>Hemos evaluado 7 parametros del sistema del complemento (c3, c4, factor b, c3a, c4a, ic3b y tcc) en 61 pacientes con les con la finalidad de estudiar sus interrelaciones y su eficacia como indicadores de actividad de esta enfermedad. Las muestras se recogieron en tubos que contenian edta\/futhan (amersham) y el plasma se almaceno a -70 grados c antes del ensayo. C3, c4 y el factor b se determinaron por nefelometria; c3a y c4a por ria (amersham) e ic3b, c3a y tcc por elisa (quidel, progen, bherung). Para definir la actividad de la enfermedad se utilizo el sledai, segun el cual clasificamos a 22 pacientes como activos y a 39 como inactivos. Los les en fase activa mostraron niveles superiores de c3a, c4a y tcc en comparacion con los pacientes inactivos y los sujetos del grupo control. Las concentraciones plasmaticas de estos productos de conversion del grupo control. Las concentraciones plasmaticas de estos productos de conversion del complemento se correlacionaron de forma positiva con la puntuacion otorgada en la escala de actividad. No obstante, ic3b y el factor b no se modificaron con las exarcebaciones de la enfermedad. En conjunto, el tcc fue el parametro de mayor utilidad (80% de eficacia) para monitorizar la actividad lupica, por lo que su determinacion rutinaria en el laboratorio podria ser muy beneficiosa con tales propositos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Activacion del complemento en el lupus eritematoso sistemico (les)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Activacion del complemento en el lupus eritematoso sistemico (les) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Manuel Porcel P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miquel Vilardell Tarres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Sim\u00f3 Schwartz Riera <\/li>\n<li>Manuel Rubio Caballero (vocal)<\/li>\n<li>Munther A. Khamashta (vocal)<\/li>\n<li> Bosch Gil Jos\u00e9 A. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Manuel Porcel P\u00e9rez Hemos evaluado 7 parametros del sistema del complemento (c3, c4, factor b, c3a, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,139,877],"tags":[259903,60945,18855,13703,211384,14062],"class_list":["post-145029","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-medicina-interna","category-reumatologia","tag-bosch-gil-jose-a","tag-jose-manuel-porcel-perez","tag-manuel-rubio-caballero","tag-miquel-vilardell-tarres","tag-munther-a-khamashta","tag-simo-schwartz-riera"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=145029"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145029\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=145029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=145029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=145029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}