{"id":145041,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":""},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"estudio-inmunofenotipico-y-analisis-genotipico-en-los-linfomas-cutaneos-de-celulas-t-micosis-fungoide-sindrome-de-sezary-pseudolinfomas-cutaneos-t-y-erupciones-cutaneas-potencialmente-prelinfomatos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-inmunofenotipico-y-analisis-genotipico-en-los-linfomas-cutaneos-de-celulas-t-micosis-fungoide-sindrome-de-sezary-pseudolinfomas-cutaneos-t-y-erupciones-cutaneas-potencialmente-prelinfomatos\/","title":{"rendered":"Estudio inmunofenotipico y analisis genotipico en los linfomas cutaneos de celulas t (micosis fungoide\/sindrome de sezary), pseudolinfomas cutaneos t y erupciones cutaneas potencialmente prelinfomatosas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ramon Mar\u00eda Pujol Vallverdu <\/strong><\/h2>\n<p>Se estudia el valor diagnostico del estudio inmunofenotipico y del analisis genotipico en muestras de sangre periferica, biopsias ganglionares y cutaneas en pacientes con un linfoma cutaneo de celulas t (micosis fungoide (mf)\/sindrome de sezaly (ss)) en distintos estadios (30 pacientes) valorando la utilidad de estas tecnicas en la diferenciacion de este proceso, con grupos de pacientes con lesiones cutaneas potencialmente prelinfomatosas (lpp) o simuladoras de un verdadero lcct (lps). Se valora la expresion de distintos antigenos lifnoides de superficie (antigenos de maduracion, moleculas de adhesion, antigenos de captacion) en los infiltrados cutaneos y muestras de sangre periferica, evaluando la posible perdida de expresion de antigenos linfoides t maduros (cd7, leu-8, cd11a). Se comparan dichos resultados con la demostracion de clonalidad linfoide t en las distintas muestras.  se detecto alteracion en la expresion antigenica en la sangre periferica en todos los pacientes con un ss y en un 10% de los pacientes con mf. La perdida de expresion antigenica en las biopsias cutaneas se observo en un 30% de pacientes con lcct y solo de forma ocasional en lesiones de lpp o lps. Los resultados del analisis genotipico confirmaron el interes de esta tecnica en la valoracion de la afectacion de sangre periferica, ganglios y en las lesiones nodulares de lcct. Sin embargo, su utilidad diagnostica parece mas limitada en las lesiones incipientes. En todos los pacientes con lpp y en un 90% de lps se observo un patron germinal.  los resultados de este estudio confirman el interes de la aproximacion diagnostica combinada del estudio inmunofenotipico y del analisis genotipico en el estudio de la lcct y en su posible diferenciacion con lesiones de lpp o lps.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio inmunofenotipico y analisis genotipico en los linfomas cutaneos de celulas t (micosis fungoide\/sindrome de sezary), pseudolinfomas cutaneos t y erupciones cutaneas potencialmente prelinfomatosas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio inmunofenotipico y analisis genotipico en los linfomas cutaneos de celulas t (micosis fungoide\/sindrome de sezary), pseudolinfomas cutaneos t y erupciones cutaneas potencialmente prelinfomatosas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ramon Mar\u00eda Pujol Vallverdu <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Moragas Vi\u00f1as<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Cirilo Rozman Borsmar <\/li>\n<li> Estrach Pa\u00f1ella M. Teresa (vocal)<\/li>\n<li>Carlos Ferr\u00e1ndiz Foraster (vocal)<\/li>\n<li>Antoni Castells Rodellas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ramon Mar\u00eda Pujol Vallverdu Se estudia el valor diagnostico del estudio inmunofenotipico y del analisis genotipico en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,97,218,139],"tags":[217,158,197,259920,115726,43532],"class_list":["post-145041","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-dermatologia","category-hematologia","category-medicina-interna","tag-antoni-castells-rodellas","tag-carlos-ferrandiz-foraster","tag-cirilo-rozman-borsmar","tag-estrach-panella-m-teresa","tag-jose-moragas-vinas","tag-ramon-maria-pujol-vallverdu"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145041","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=145041"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145041\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=145041"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=145041"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=145041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}