{"id":14505,"date":"2018-03-09T09:01:14","date_gmt":"2018-03-09T09:01:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-de-la-actividad-proliferativa-celular-en-los-tumores-de-celulas-germinales-del-testiculo\/"},"modified":"2018-03-09T09:01:14","modified_gmt":"2018-03-09T09:01:14","slug":"valoracion-de-la-actividad-proliferativa-celular-en-los-tumores-de-celulas-germinales-del-testiculo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valoracion-de-la-actividad-proliferativa-celular-en-los-tumores-de-celulas-germinales-del-testiculo\/","title":{"rendered":"Valoraci\u00f3n de la actividad proliferativa celular en los tumores de c\u00e9lulas germinales del testiculo"},"content":{"rendered":"

Tesis doctoral de Emilio Merchante Somalo <\/strong><\/h2>\n

En la presente tesis doctoral se ha estudiado el ciclo celular de los tumores de c\u00e9lulas germinales testiculares del hombre y del perro. Se ha analizado si estos tumores, desarrollados en dos especies diferentes, tienen un comportamiento similar del ciclo celular, evaluado mediante m\u00e9todos inmunohistoqu\u00edmicos, densitom\u00e9tricos y morfom\u00e9tricos. Para esta investigaci\u00f3n, se han evaluado 19 seminomas cl\u00e1sicos testiculares humanos, 15 carcinomas embrionarias testiculares de hombres adultos, 8 tumores del seno endod\u00e9rmico testicular humano, asi como 9 seminomas testiculares unilaterales procedentes de perros adultos. en todos los casos, se ha valorado del ant\u00edgeno de proliferaci\u00f3n celular pcna-cilcina, usando diferentes m\u00e9todos inmunohistoqu\u00edmiocs; el m\u00e9todo de la estreptavidina – biotina – peroxidasa revelado con diaminobenmcidina, con o sin tinci\u00f3n nuclear de hematoxilina, y el m\u00e9todo fosfatasa alcalina – anti fosfatasa alcalina revelado con fast red, cono sin tinci\u00f3n nuclear de hematoxilina. Se concluye que para la cuantificaci\u00f3n de la expresi\u00f3n del pcna el m\u00e9todo m\u00e1s adecuado es el de la estreptavidina – biotina – peroxidasa, revelado con diaminobencidina y con tinci\u00f3n nuclear de hematoxilina. en el estudio, tambi\u00e9n se valoro densitom\u00e9tricamente la ploid\u00eda, mediante el m\u00e9todo feulgen, determinando la densidad optica integrada de las cargas de dna. Los tumores de c\u00e9lulas germinales del test\u00edculo humano presentan un incremento significativo de la cantidad de dna con respecto a las c\u00e9lulas normales. Adem\u00e1s, la superficie nuclear es significativamente mayor en el carcinoma embrionario que en los otros tipos de tumores de c\u00e9lulas germinales desarrollados en el test\u00edculo humano. la comparaci\u00f3n de los par\u00e1metros del ciclo celular en los siminomas del hombre y del perro surgiere que los seminomas desarrollados en ambas especies tienen una actividad proliferativa y una capacidad de s\u00edntesis de dna semejante, lo<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abValoraci\u00f3n de la actividad proliferativa celular en los tumores de c\u00e9lulas germinales del testiculo<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Valoraci\u00f3n de la actividad proliferativa celular en los tumores de c\u00e9lulas germinales del testiculo <\/li>\n
  • Autor:<\/strong>\u00a0 Emilio Merchante Somalo <\/li>\n
  • Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2001<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • JavierFrancisco Regadera Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Mar\u00eda Casta\u00f1o rosado <\/li>\n
        • pilar Gonz\u00e1lez-peramato gutier (vocal)<\/li>\n
        • Nistal mart\u00ednez de serr Manuel (vocal)<\/li>\n
        • Emilio Burgos lizalde (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Emilio Merchante Somalo En la presente tesis doctoral se ha estudiado el ciclo celular de los tumores […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,9,515,156,1323,495],"tags":[46666,46663,14273,5215,46665,46664],"class_list":["post-14505","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-medicas","category-ciencias-veterinarias","category-patologia","category-patologia-experimental","category-patologia-veterinaria","tag-emilio-burgos-lizalde","tag-emilio-merchante-somalo","tag-javierfrancisco-regadera-gonzalez","tag-maria-castano-rosado","tag-nistal-Martinez-de-serr-manuel","tag-pilar-gonzalez-peramato-gutier"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14505","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=14505"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14505\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=14505"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=14505"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=14505"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}