{"id":145082,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudis-estructurals-amb-inhibidors-de-procarboxipeptidases-pancreatiques\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"estudis-estructurals-amb-inhibidors-de-procarboxipeptidases-pancreatiques","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudis-estructurals-amb-inhibidors-de-procarboxipeptidases-pancreatiques\/","title":{"rendered":"Estudis estructurals amb inhibidors de procarboxipeptidases pancreatiques"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miquel Salva Coll <\/strong><\/h2>\n<p>En esta tesis se han llevado a cabo diferentes estudios sobre el mecanismo de activacion de las procarboxipeptidasas pancreaticas, utilizando metodos como la secuenciacion manual de peptidos con el reactivo dabitc, la resonancia magnetica nuclear bidimensional de proteinas y los metodos de dinamica molecular. El analisis detallado del proceso de activacion in vitro con tripsina de las procarboxipeptidasas a y b porcinas (pcpa y pcpb), permitio proponer un mecanismo comun de conversion de zimogeno a enzima para estos dos proenzimas. Durante el proceso tienen lugar dos cortes tripticos en la region n-terminal del proenzima que liberan al medio de reaccion carboxipeptidasa activa (cp), un peptido de unos 70-80 residuos (segmento o dominio de activacion (sa)) y un peptido de entre 10-20 residuos (fragmento de union (fu)). Los sa presentan en disolucion una estructura 3d definida formada por dos helices alfa y una hoja beta de 3-4 cadenas antiparalelas. Los metodos de dinamica molecular han permitido predecir una conformacion tridimensional estable para el fu de la pcpa porcina y que consiste en una helice alfa sobre la que se pliega el extremo n-terminal del peptido. La conformacion del fu es similar a la de una hormona peptidica aislada de pancreas de pollo, lo que sugiere tambien para el fu de las pcp una posible funcion secundaria de tipo hormonal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudis estructurals amb inhibidors de procarboxipeptidases pancreatiques<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudis estructurals amb inhibidors de procarboxipeptidases pancreatiques <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miquel Salva Coll <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francesc Xavier Avil\u00e9s Puigvert<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Cortes Tejedor <\/li>\n<li>Fernando Climent Romeo (vocal)<\/li>\n<li>Mar\u00eda Vilanova Brugues (vocal)<\/li>\n<li>Enrique Mendez Corman (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miquel Salva Coll En esta tesis se han llevado a cabo diferentes estudios sobre el mecanismo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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