{"id":145115,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacocinetico-farmacodinamico-del-tramadol-utilizado-como-analgesico-en-el-periodo-postoperatorio\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"estudio-farmacocinetico-farmacodinamico-del-tramadol-utilizado-como-analgesico-en-el-periodo-postoperatorio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacocinetico-farmacodinamico-del-tramadol-utilizado-como-analgesico-en-el-periodo-postoperatorio\/","title":{"rendered":"Estudio farmacocinetico-farmacodinamico del tramadol utilizado como analgesico en el periodo postoperatorio."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Tarradell Zamora Rosa M. <\/strong><\/h2>\n<p>El dolor postoperatorio debe ser controlado rapidamente para disminuir los efectos indeseables que puede ocasionar en la recuperacion del paciente. Los objetivos de este estudio fueron: 1) comparar el efecto analgesico de la meperidina (mp) y el tramadol (tr) administrados en bolus por via ev en el periodo postoperatorio, b) correlacionar los efectos analgesicos con las concentraciones plasmaticas, c) la incidencia y caracteristicas de los efectos secundarios.  se estudiaron 24 pacientes asa i-ii intervenidos de protesis total de cadera o rodilla con anestesia general inhalatoria. En la sala de reanimacion, los pacientes fueron asignados de forma randomizada a uno de los tres grupos del estudio. Cuando lo solicitaron recibieron (a doble ciego) el rescate farmacologico: suero salino (ss), 100 mg mp o 100 mg tr. Se evaluaron en ese momento y a diferentes tiempos hasta las cuatro horas: dolor, sedacion, fc, ta, fr, volumen tidal, sat o2, pa co2 y muestras sanguineas para la determinacion de los niveles plasmaticos de mp, tr y m1. Los pacientes que precisaron analgesia suplementaria (as) recibieron diclofenac (75 mg) a los 30 minutos despues del rescate.  los resultados obtenidos demuestran que la mp y el tr proporcionaron analgesia significativa a lo largo de todo el estudio. Todos los pacientes del grupo que recibio ss y la mitad de los que recibieron mp o tr, precisaron as.  cuando los niveles plasmaticos de ambos farmacos se correlacionaron con la pid se obtuvieron los coeficientes: mp r= -0.82, tr r=-0.91 y m1 r= 0.61.  los parametros farmacocineticos fueron similares para los dos farmacos. Mp produce depresion respiratoria de forma significativa ( pa co2, vtidal, fr, p&lt;0.05) y sedacion (ramsay p&lt;0.05), en comparacion con tr.  en conclusion: a) la mp produce mayor incidencia de efectos indeseables en comparacion con tr, b) la correlacion entre los niveles plasmaticos y la analgesia obtenida sugiere que los metabolitos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocinetico-farmacodinamico del tramadol utilizado como analgesico en el periodo postoperatorio.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocinetico-farmacodinamico del tramadol utilizado como analgesico en el periodo postoperatorio. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Tarradell Zamora Rosa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Puig De Conias Margarita M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Lopez Timoneda <\/li>\n<li>Mar\u00eda Luisa Laorden Carrasco (vocal)<\/li>\n<li>Luis Aliaga Font (vocal)<\/li>\n<li>Mar\u00eda Victoria Milan\u00e9s Maquil\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tarradell Zamora Rosa M. El dolor postoperatorio debe ser controlado rapidamente para disminuir los efectos indeseables que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1569,9,141,25911],"tags":[5896,34812,8548,8481,244758,260008],"class_list":["post-145115","post","type-post","status-publish","format-standard","hentry","category-anestesiologia-quirurgica","category-ciencias-medicas","category-cirugia","category-medicina-paliativa","tag-francisco-lopez-timoneda","tag-luis-aliaga-font","tag-maria-luisa-laorden-carrasco","tag-maria-victoria-milanes-maquilon","tag-puig-de-conias-margarita-m","tag-tarradell-zamora-rosa-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=145115"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145115\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=145115"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=145115"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=145115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}