{"id":145265,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-del-gen-de-la-hormona-de-crecimiento-gh-de-rata-por-diferentes-miembros-de-la-superfamilia-de-receptores-nucleares\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"regulacion-del-gen-de-la-hormona-de-crecimiento-gh-de-rata-por-diferentes-miembros-de-la-superfamilia-de-receptores-nucleares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/regulacion-del-gen-de-la-hormona-de-crecimiento-gh-de-rata-por-diferentes-miembros-de-la-superfamilia-de-receptores-nucleares\/","title":{"rendered":"Regulacion del gen de la hormona de crecimiento (gh) de rata por diferentes miembros de la superfamilia de receptores nucleares"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Pilar Garcia Villalba Guillamon <\/strong><\/h2>\n<p>La expresion del gen de la hormona de crecimiento (gh) de rata, es especifica de las celulas somatotropas de la adenohipofisis. La expresion de este gen esta regulada transcripcionalmente por diferentes factores hormonales.  en esta tesis mostramos que en la linea hipofisaria gh4c1 el acido retinoico (ra), al igual que las hormonas tiroideas (t3) regulan la transcripcion del gen de gh a traves de las mismas secuencias localizadas en la region 5 del gen. Los glucocorticoides aumentan los niveles de mrna de gh pero no aumentan la actividad basal del promotor de gh ni la respuesta a la t3 o al ra. La cotransfeccion del promotor de gh con un vector de expresion para el receptor de t3 produjo un aumento de la respuesta a la t3 pero bloqueo la respuesta al ra y viceversa.  nuestros resultados muestran que ambos receptores compiten por el elemento de respuesta. El receptor x de retinoides rxr aumento la transactivacion por t3 y ra; la 1,25-dihidroxivitamina d3, ligando de otro miembro de la superfamilia de receptores nucleares, no altero la expresion basal del promotor de gh pero disminuyo la estimulacion producida por la t3 o el ra. Esta inhibicion se produce a traves del elemento de respuesta comun a t3\/ra. El butirato, acido graso de cadena corta, produce modificaciones postsinteticas en las proteinas de la cromatina, modifico la actividad del promotor del gen de gh y su regulacion por la t3 y el ra. Estos resultados muestran las complejas interacciones existentes entre los distintos miembros de la superfamilia de los receptores hormonales y la importancia de la estructura de la cromatina en la regulacion del gen de la gh.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion del gen de la hormona de crecimiento (gh) de rata por diferentes miembros de la superfamilia de receptores nucleares<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion del gen de la hormona de crecimiento (gh) de rata por diferentes miembros de la superfamilia de receptores nucleares <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Pilar Garcia Villalba Guillamon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Aranda Iriarte<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Dieguez Gonzalez <\/li>\n<li>M\u00aa Josefa Toro Nozal (vocal)<\/li>\n<li>Rafael Garese (vocal)<\/li>\n<li>Ignacio Torres Aleman (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Pilar Garcia Villalba Guillamon La expresion del gen de la hormona de crecimiento (gh) de rata, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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