{"id":145270,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-sintesis-del-factor-de-necrosis-tumoral-alfa-mediante-la-produccion-endogena-de-pge2-en-respuesta-a-la-perfusion-de-somatostatina-14\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"modulacion-de-la-sintesis-del-factor-de-necrosis-tumoral-alfa-mediante-la-produccion-endogena-de-pge2-en-respuesta-a-la-perfusion-de-somatostatina-14","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-de-la-sintesis-del-factor-de-necrosis-tumoral-alfa-mediante-la-produccion-endogena-de-pge2-en-respuesta-a-la-perfusion-de-somatostatina-14\/","title":{"rendered":"Modulacion de la sintesis del factor de necrosis tumoral alfa mediante la produccion endogena de pge2 en respuesta a la perfusion de somatostatina 14."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Remedios Gomez Sanz <\/strong><\/h2>\n<p>La elevada incidencia y mortalidad del shock septico y sus secuelas hacen que este siga siendo un tema de gran interes. Sabemos la importancia que poseen los mediadores sintetizados por el huesped en respuesta a la endotoxina, fundamentalmente del factor de necrosis tumoral alfa. Nos planteamos un ensayo en el que pretendemos modular su sintesis potenciando el circulo autorregulador entre tnf y pge2. Para ello administramos una solucion de somatostatina 14, capaz de estimular la sintesis de pge2, a un grupo de ratas comparando los resultados con los obtenidos en otro grupo al que se administra suero fisiologico. Clinicamente, todos los animales que recibieron suero presentaron alteraciones clinicas y anatomopatologicas y niveles de tnf superiores significativamente respecto a los que recibieron somatostatina, asi como niveles de pge2 inferiores.  concluimos diciendo que la perfusion con ss-14 es capaz de modular la sintesis de tnf mediante la estimulacion endogena de pge2 y disminuir las manifestaciones clinicas y anatomopatologicas en respuesta a la endotoxina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion de la sintesis del factor de necrosis tumoral alfa mediante la produccion endogena de pge2 en respuesta a la perfusion de somatostatina 14.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion de la sintesis del factor de necrosis tumoral alfa mediante la produccion endogena de pge2 en respuesta a la perfusion de somatostatina 14. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Remedios Gomez Sanz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Balibrea  Cantero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Garcia  Sancho Martin <\/li>\n<li>Miguel Angel Dapena Crespo (vocal)<\/li>\n<li>Antonio  Jos\u00e9 Torres Garc\u00eda (vocal)<\/li>\n<li>Alfredo Abad Barahona (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Remedios Gomez Sanz La elevada incidencia y mortalidad del shock septico y sus secuelas hacen que este [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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