{"id":145400,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-del-gen-del-factor-de-transcripcion-ghf-1-interaccion-con-los-receptores-de-hormonas-tiroideas-y-acido-retinoico\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"expresion-del-gen-del-factor-de-transcripcion-ghf-1-interaccion-con-los-receptores-de-hormonas-tiroideas-y-acido-retinoico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/expresion-del-gen-del-factor-de-transcripcion-ghf-1-interaccion-con-los-receptores-de-hormonas-tiroideas-y-acido-retinoico\/","title":{"rendered":"Expresion del gen del factor de transcripcion ghf-1. interaccion con los receptores de hormonas tiroideas y acido retinoico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aurora Sanchez Pacheco <\/strong><\/h2>\n<p>En este trabajo se han estudiado algunos aspectos de la regulacion del gen que codifica para el factor de transcripcion ghf-1. En una primera parte los resultados obtenidos indican que t3 y ra regulan transcripcionalmente la expresion del gen ghf-1. La t3 produce una disminucion en los niveles de mrna y proteina ghf-1, mientras que el ra produce un aumento en dichos niveles. El efecto de t3 parece ser mediado por secuencias cre y en concreto por las proteinas que se unen a estas secuencias, las proteinas creb.  hemos analizado tambien el efecto de tpa y fk. Ambos agentes producen una estimulacion de los niveles de mensajero de ghf-1, regulando su transcripcion a traves de sitios cres.  en la segunda parte de nuestro trabajo, analizamos la interaccion entre ghf-1 y los receptores de t3 y ra sobre el promotor del gen de gh. Hemos observado que existe una interaccion funcional entre ellos, resultando en una respuesta sinergica a la estimulacion producida por t3 y ra en la expresion del gen de gh. Nuestros datos indican que existe una interaccion fisica proteina proteina. Por lo tanto ghf-1 no solo es necesario para la actividad basal del gen de gh sino que tambien coopera sinergisticamente con los receptores de hormonas tiroideas y acido retinoico incrementando la expresion del gen de gh. En una tercera parte analizamos el papel de la proteina ghf-2 resultante del procesamiento alternativo del gen de ghf-1 en cuanto a la actividad del gen de gh se refiere.  los resultados obtenidos nos indican que ghf-2 actua como un agente inhibidor de la accion de ghf-1. Siendo capaz de inhibir la actividad inducida por t3 y ra del promotor del gen de gh.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion del gen del factor de transcripcion ghf-1. interaccion con los receptores de hormonas tiroideas y acido retinoico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion del gen del factor de transcripcion ghf-1. interaccion con los receptores de hormonas tiroideas y acido retinoico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aurora Sanchez Pacheco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Aranda Iriarte<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Dieguez Gonzalez <\/li>\n<li>Jos\u00e9 Manuel Cuezva Marcos (vocal)<\/li>\n<li>Pilar Santisteban Sanz (vocal)<\/li>\n<li>Josefa Predestinaci\u00f3n Garc\u00eda Ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aurora Sanchez Pacheco En este trabajo se han estudiado algunos aspectos de la regulacion del gen que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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