{"id":145865,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-glucosa-en-los-procesos-bioquimicos-y-funcionales-de-la-celula-b-pancreatica-tumoral-linea-rinm5f\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"la-glucosa-en-los-procesos-bioquimicos-y-funcionales-de-la-celula-b-pancreatica-tumoral-linea-rinm5f","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/la-glucosa-en-los-procesos-bioquimicos-y-funcionales-de-la-celula-b-pancreatica-tumoral-linea-rinm5f\/","title":{"rendered":"La glucosa en los procesos bioquimicos y funcionales de la celula b pancreatica tumoral: linea rinm5f."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Galera Mayor <\/strong><\/h2>\n<p>Se ha determinado en la linea celular rinm5f, linea continua de celulas de islotes pancreaticos tumorales, concentracion de glucosa que caracteriza el efecto crabhree, inducido a diferentes concentraciones la proporcion de consumo de d-(6-14c) glucosa en procesos mitocondriales en relacion a la utilizacion total de d-(5-3h) glucosa. El siguiente paso consistio en la busqueda de posibles alteraciones de las variables metabolicas y funcionales de las celulas tumorales pancreaticas en las que se habia provocado un descenso en la tasa de proliferacion utilizando la d,l-alfa-difluorometilornitina o dfmo.  por tanto se estudio el metabolismo de la glucosa en celulas rinm5f control y tratadas con dfmo a distintos niveles, utilizando distintos precursores radiactivos: via de las pentosas, lanzadera del glicerol fostato, interconversion de las triosas fosfato, produccion de alamina, acido lactico y acido piruvico, descarboxilacion del acido piruvico a acetil coa, oxidacion en el ciclo de krebs y produccion de aminoacidos y metabolitos acidos. Tambien se estudio la dependencia de algunos procesos del ion ca2+, la estimulacion que produce la glucosa sobre la biosintesis de insulina y proteinas.  con todo esto se ha intentado determinar si el cese de la proliferacion celular de la linea rinm5f restaura el patron de consumo y utilizacion de la glucosa, propio de los islotes pancreaticos normales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La glucosa en los procesos bioquimicos y funcionales de la celula b pancreatica tumoral: linea rinm5f.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La glucosa en los procesos bioquimicos y funcionales de la celula b pancreatica tumoral: linea rinm5f. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Galera Mayor <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Valverde Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: W.j. Malaisse <\/li>\n<li>Luis Monge (vocal)<\/li>\n<li>Javier Camara (vocal)<\/li>\n<li>Luisa Villanueva-pe\u00f1acarrillo M. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Galera Mayor Se ha determinado en la linea celular rinm5f, linea continua de celulas de islotes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,160,13696,17],"tags":[260791,5536,257710,179878,14889,260792],"class_list":["post-145865","post","type-post","status-publish","format-standard","hentry","category-alcala","category-bioquimica","category-glucidos","category-quimica","tag-carlos-galera-mayor","tag-isabel-valverde-alonso","tag-javier-camara","tag-luis-monge","tag-luisa-villanueva-penacarrillo-m","tag-w-j-malaisse"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=145865"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145865\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=145865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=145865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=145865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}