{"id":145940,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-respuesta-humoral-frente-al-virus-de-la-hepatitis-c-mediante-peptidos-sinteticos-aplicacion-al-diagnostico\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"estudio-de-la-respuesta-humoral-frente-al-virus-de-la-hepatitis-c-mediante-peptidos-sinteticos-aplicacion-al-diagnostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-de-la-respuesta-humoral-frente-al-virus-de-la-hepatitis-c-mediante-peptidos-sinteticos-aplicacion-al-diagnostico\/","title":{"rendered":"Estudio de la respuesta humoral frente al virus de la hepatitis c mediante peptidos sinteticos. aplicacion al diagnostico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Del Carmen Berasain Lasarte <\/strong><\/h2>\n<p>Se estudio la respuesta humoral en pacientes con hepatitis nanb cronica y aguda utilizando peptidos sinteticos. La mayoria de los epitopes inmunodominantes se encontraron en el extremo amino-terminal del core, aunque tambien se encontro un epitope importante en la proteina ns4. Los pacientes con hepatitis aguda c presentaron una mayor preValencia de anticuerpos que los pacientes con hepatitis cronica. Esta preValencia fue superior en los pacientes con hepatitis aguda c que no resolvieron la infeccion que en los que la resolvieron.  el 4,7% de las hepatitis cronicas nanb y el 25,7% de las hepatitis agudas nanb se clasificaron como hepatitis nanbnc. Utilizando peptidos especificos de los genotipos i y ii se encontro que el genotipo i es prevalente en la poblacion estudiada. Con peptidos especificos del tipo 1 y 2 del vhc (machida et al hepatol. 16:886-91,1992) se encontro que el tipo 1 es prevalente y que la infeccion por el tipo 2 esta significativamente asociada con la respuesta completa al tratamiento con interferon. Se desarrollo un ensayo elisa para el diagnostico de la hepatitis c, utilizando como antigeno un heteropolimero de 3 peptidos sinteticos (hp). Su especificidad es significativamente superior a la del ensayo de 2 generacion de ortho (o2) (99,3 vs 90,1%, p&lt;0,001). La sensibilidad del ensayo o2 es ligeramente superior a la del ensayo hp en las hepatitis agudas (96,1 vs 84,6%) y en las cronicas (100 vs 99,5), pero las diferencias no son significativas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la respuesta humoral frente al virus de la hepatitis c mediante peptidos sinteticos. aplicacion al diagnostico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la respuesta humoral frente al virus de la hepatitis c mediante peptidos sinteticos. aplicacion al diagnostico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Del Carmen Berasain Lasarte <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Borras Cuesta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas M. Prieto Valtue\u00f1a <\/li>\n<li>Javier Diaz Martinez (vocal)<\/li>\n<li>Beatriz Amorena Zabalza (vocal)<\/li>\n<li>Alfonso Sanchez Ibarrola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Del Carmen Berasain Lasarte Se estudio la respuesta humoral en pacientes con hepatitis nanb cronica y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,35,1737,17749,969,17,1775],"tags":[13420,28739,18184,260869,15059,80799],"class_list":["post-145940","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-ciencias-de-la-vida","category-inmunologia","category-navarra","category-peptidos","category-quimica","category-reaccion-antigeno-anticuerpo","tag-alfonso-sanchez-ibarrola","tag-beatriz-amorena-zabalza","tag-francisco-borras-cuesta","tag-javier-diaz-Martinez","tag-jesus-m-prieto-valtuena","tag-maria-del-carmen-berasain-lasarte"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=145940"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145940\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=145940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=145940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=145940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}