{"id":145961,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-y-evaluacion-farmacologica-preliminar-de-nuevos-inhibidores-de-transcriptasa-inversa-de-vih-1-derivados-de-indol\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"sintesis-y-evaluacion-farmacologica-preliminar-de-nuevos-inhibidores-de-transcriptasa-inversa-de-vih-1-derivados-de-indol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sintesis-y-evaluacion-farmacologica-preliminar-de-nuevos-inhibidores-de-transcriptasa-inversa-de-vih-1-derivados-de-indol\/","title":{"rendered":"Sintesis y evaluacion farmacologica preliminar de nuevos inhibidores de transcriptasa inversa de vih-1 derivados de indol"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alfredo Elorriaga Soriano <\/strong><\/h2>\n<p>El sida es una enfermedad infectocontagiosa causada por el virus de la inmunodeficien humana. Este es un retrovirus que tiene su informacion genetica en forma de arn, por lo que para expresarse necesita ser transcrito a adn. Este proceso de transcripcion tiene lugar en el interior de los linfocitos t4, y su destruccion es la responsable de las manifestaciones clinicas del sida. La transcripcion se lleva a cabo por medio de la enzima transcriptasa inversa que ha demostrado ser una de las dianas mas efectivas a la hora de atajar la enfermedad.  con este fin se han sintetiado 38 nuevos productos derivados de indol tomando como base los trabajos publicados sobre inhibidores especificos de transcriptasa inversa de vih-1, de los cuales 25 se han evaluado en un ensayo de inhibicion de transcriptasa inversa de vih-1.  los tres productos mas interesantes del trabajo se evaluaron como inhibidores de la variedad mutante p236l de la transcriptasa inversa de vih-1 y como inhibidores de la formacion de sincitios inducida por vih-1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y evaluacion farmacologica preliminar de nuevos inhibidores de transcriptasa inversa de vih-1 derivados de indol<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y evaluacion farmacologica preliminar de nuevos inhibidores de transcriptasa inversa de vih-1 derivados de indol <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alfredo Elorriaga Soriano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Aldana Moraza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Esteban Santiago Calvo <\/li>\n<li> Martinez Remirez Mar\u00eda  Teresa (vocal)<\/li>\n<li>Juan  Antonio Palop Cubillo (vocal)<\/li>\n<li> Ramirez Medrano Mar\u00eda  Del Carmen (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alfredo Elorriaga Soriano El sida es una enfermedad infectocontagiosa causada por el virus de la inmunodeficien humana. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,1412,2445,957,17749,17,416],"tags":[260890,17968,91383,17931,32120,260891],"class_list":["post-145961","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-compuestos-heterociclicos","category-evaluacion-de-farmacos","category-farmacologia","category-navarra","category-quimica","category-quimica-organica","tag-alfredo-elorriaga-soriano","tag-esteban-santiago-calvo","tag-ignacio-aldana-moraza","tag-juan-antonio-palop-cubillo","tag-Martinez-remirez-maria-teresa","tag-ramirez-medrano-maria-del-carmen"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=145961"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145961\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=145961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=145961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=145961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}