{"id":145980,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/patogenesis-de-la-disfuncion-precoz-del-injerto-en-el-trasplante-hepatico-valoracion-de-los-leucotrienos-y-el-tromboxano-como-marcadores-de-lipoperoxidacion\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"patogenesis-de-la-disfuncion-precoz-del-injerto-en-el-trasplante-hepatico-valoracion-de-los-leucotrienos-y-el-tromboxano-como-marcadores-de-lipoperoxidacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/patogenesis-de-la-disfuncion-precoz-del-injerto-en-el-trasplante-hepatico-valoracion-de-los-leucotrienos-y-el-tromboxano-como-marcadores-de-lipoperoxidacion\/","title":{"rendered":"Patogenesis de la disfuncion precoz del injerto en el trasplante hepatico. valoracion de los leucotrienos y el tromboxano como marcadores de lipoperoxidacion."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Gonzalez Fernandez <\/strong><\/h2>\n<p>El da\u00f1o por isquemia-reperfusion causa la perdida precoz de muchos aloinjertos hepaticos. Este trabajo pretende valorar esta lesion cuantificando la lipoperoxidacion de membrana, mediante la determinacion de los niveles de diferentes metabolitos del acido araquidonico. Material y metodos: se realizaron 18 alotrasplantes en perros de 15-30 kg., Preservando el injerto con eurocollins (grupo i: 2-4 c, n = 9; grupo ii: 10-15 grados c, n = 9). Se midieron leucotrieno b4 -ltb4-, ltc4, tromboxano b2 -txb2-, y test de funcion hepatica y coagulacion, en fase basal, de hepatectomia, anhepatica, postrepercusion (15 m, 1 h., 2 h., 5 h., 8 h., 24 h.) Y diariamente hasta el fallecimiento.  resultados: la supervivencia media del grupo i fue de 4,1 +- 3,6 dias, muriendo 5 animales por rechazo. En el grupo ii no hubo supervivencia superiores a 24 h. Y todas las biopsias postreperfusion mostraron una necrosis severa.  tras la revascularizacion se elevaron los 3 metabolitos del araquidonico, excepto el ltc4 en el grupo ii, que no fue detectable. El aumento del ltb4 y del txb2 fue significativamente mayor en el grupo ii (fase 2h: txb2 = 681 +- 279 ng\/ml vs 1092 +- 365, ltb4 = 71 +- 50 pg\/ml vs 123 +- 49, p&lt;0,05). El ltb4 presento indices de correlacion 0,75 o &lt; -0,75 con siete parametros de viabilidad del injerto.  conclusiones el da\u00f1o por isquemia-reperfusion produce aumenta la lipoperoxidacion de membrana, siendo detectable por un incremento en los niveles sanguineos de diferentes metabolitos del acido araquidonico. En este modelo, los niveles de ltb4, a diferencia del ltc4 y del txb2, se relacionan fuertemente con los de los parametros de viabilidad de linjerto.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Patogenesis de la disfuncion precoz del injerto en el trasplante hepatico. valoracion de los leucotrienos y el tromboxano como marcadores de lipoperoxidacion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Patogenesis de la disfuncion precoz del injerto en el trasplante hepatico. valoracion de los leucotrienos y el tromboxano como marcadores de lipoperoxidacion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Gonzalez Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>cienfuegos Suarez Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Vazquez Garcia <\/li>\n<li>Carlos Margarit Creixell (vocal)<\/li>\n<li>Enrique Martinez Rodriguez (vocal)<\/li>\n<li>Gerardo Zornoza Celaya (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Gonzalez Fernandez El da\u00f1o por isquemia-reperfusion causa la perdida precoz de muchos aloinjertos hepaticos. Este trabajo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,10,1279,17749],"tags":[33803,32045,8848,17894,260916,17888],"class_list":["post-145980","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-de-trasplantes","category-cirugia-experimental","category-navarra","tag-carlos-margarit-creixell","tag-cienfuegos-suarez-alvarez","tag-enrique-Martinez-rodriguez","tag-gerardo-zornoza-celaya","tag-jesus-gonzalez-fernandez","tag-jesus-vazquez-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145980","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=145980"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/145980\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=145980"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=145980"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=145980"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}