{"id":146022,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/urokinasa-combinada-con-poliquimioterapia-alternante-radioterapia-toracica-y-holocraneal-en-el-carcinoma-microcitico-de-pulmon\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"urokinasa-combinada-con-poliquimioterapia-alternante-radioterapia-toracica-y-holocraneal-en-el-carcinoma-microcitico-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/urokinasa-combinada-con-poliquimioterapia-alternante-radioterapia-toracica-y-holocraneal-en-el-carcinoma-microcitico-de-pulmon\/","title":{"rendered":"Urokinasa combinada con poliquimioterapia alternante, radioterapia toracica y holocraneal en el carcinoma microcitico de pulmon."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ortiz De Urbina Ugarte David Ignacio <\/strong><\/h2>\n<p>Entre julio-82 y julio 87, 51 ptes (e. Limitada: 27, e.  extensa: 24) con diagnostico de carcinoma microcitico de pulmon (cmp), han sido incluidos en un programa de tratamiento consistente en la combinacion de urokinasa (uk) 3.000 ui\/kg bolus iv, seguido de 3.000 ui\/kg\/h x 6 horas y poliquimioterapia sistemica, ciclos alternantes consistentes en ciclofosfamida 1000 mg\/m2, adriamicina 50 mg\/m2, vincristina 1,4 mg\/m2 (cav) y cisplatino 100 mg\/m2, etoposido 250 mg\/m2 x 2 dosis y vincristina 1,4 mg\/m2 (pvp), cada 6 semanas durante 1 a\u00f1o (uk-cav\/pvp).  el grupo de pts con respuesta tumoral (rc o rp) recibieron irradiacion toracica (ti) con tecnica de split (46 gy) e irradiacion craneal profilactica (pci) (25 gy).  se administro qt de mantenimiento hasta completar 1 a\u00f1o.  en el se objetivaron 23\/27 rc (85%) (4 rc post-ti) y 4\/27 rp (15%); la mediana de tiempo a rc (mtrc) fue de 59 dias (rc post-ti: 105 dias) y la mediana de duracion de la respuesta (mdr) de 1000+ dias (27-2957+) (rc post-ti: 142 dias (160-349)).  en ee, 17\/24 rc (70,5%) (3 rc post-ti) y 4\/24 rp (16,5%), con mtrc y mdr de 59 dias (rc post-ti: 111 dias) y 308 dias (21-1.246 dias) (rc post-ti: 93 dias) respectivamente. La tasa de rc histologica al a\u00f1o fue de 59,2% (el:16) y 33,3% (ee:8). La localizacion de la primera recidiva en rc objetivo 12\/23 (52%) recurrencias en el: locorregional: 7 (30,5%) y a distancias: 5 (21,5%) y 14\/17 (82%) en ee: locorregional: 3 (17,5%) y a distancia 11 (64,5%).  en pacientes con el, la mediana de supervivencia (msv) ha sido de 795,5 dias (50-3.052+) y la supervivencia (spv) actuarial al a\u00f1o, 2,5 a\u00f1os y 5 a\u00f1os de 85,1%, 55,5% y 33,3% respectivamente. En pacientes con ee, la msv ha sido de 401 dias (54-1.333) y la spv al a\u00f1o y a los 2 a\u00f1os de 54% y 16,6% respectivamente.  la toxicidad referida a uk consistio en 4 episodios de hemoptisis leve y transitoria, 1 reaccion alergica y un accidente cerebrovascular fatal; mielotoxicidad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Urokinasa combinada con poliquimioterapia alternante, radioterapia toracica y holocraneal en el carcinoma microcitico de pulmon.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Urokinasa combinada con poliquimioterapia alternante, radioterapia toracica y holocraneal en el carcinoma microcitico de pulmon. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ortiz De Urbina Ugarte David Ignacio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Brugarolas Masllorens<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Domingo Espinos Perez <\/li>\n<li> Azanza Perea Jos\u00e9 Ramon (vocal)<\/li>\n<li> Garc\u00eda Puche Jos\u00e9 Luis (vocal)<\/li>\n<li> Calvo Manuel Felipe A. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ortiz De Urbina Ugarte David Ignacio Entre julio-82 y julio 87, 51 ptes (e. Limitada: 27, e. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,189,484,17749,347],"tags":[9012,32359,70641,897,32160,260952],"class_list":["post-146022","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-farmacodinamia","category-mecanismos-de-accion-de-la-quimioterapia","category-navarra","category-oncologia-clinica","tag-antonio-brugarolas-masllorens","tag-azanza-perea-jose-ramon","tag-calvo-manuel-felipe-a","tag-domingo-espinos-perez","tag-garcia-puche-jose-luis","tag-ortiz-de-urbina-ugarte-david-ignacio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/146022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=146022"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/146022\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=146022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=146022"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=146022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}