{"id":146030,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/peptidos-sinteticos-en-la-induccion-de-celulas-citotoxicas-antitumorales\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"peptidos-sinteticos-en-la-induccion-de-celulas-citotoxicas-antitumorales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/peptidos-sinteticos-en-la-induccion-de-celulas-citotoxicas-antitumorales\/","title":{"rendered":"\u00abpeptidos sinteticos en la induccion de celulas citotoxicas antitumorales\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Alberto P\u00e9rez Mediavilla <\/strong><\/h2>\n<p>Basandonos en la secuencia de la proteina a del staphylococcus aureus cowan i hemos sintetizado peptidos de 15 aminoacidos. Algunos de estos peptidos tienen la propiedad de inducir en celulas linfomononucleares de sangre periferica un efecto citotoxico sobre celulas tumorales. En los cultivos celulares incubados en presencia de los peptidos activos hemos detectado un aumento de la citotoxicidad sobre celulas daudi y k562.  simultaneamente se produce en los cultivos el incremento en el numero de celulas que expresan las moleculas de superficie cd11b, cd16, cd56 y cd14. Asi mismo hemos encontrado que en los cultivos con los peptidos hay unos elevados niveles de il-1 y tnf.  utilizando un antisuero anti oxido nitrico sintasa inducible se ha visto que en los cultivos aparecen celulas inmunorreactivas. Estos resultados sugieren una activacion de monocitos.  el analisis ultraestructural de las celulas activadas mostro la presencia de granos citoplasmaticos electrodensos. En el interior de estos granos se ha detectado una actividad dnasa no relacionada antigenicamente con el tnf. Esta actividad es resistente al ph acido y al tratamiento a 56 grados c durante 30 minutos. Mediante electroforesis en sds-page hemos visto que en los extractos de los granos predomina una proteina de 45 kda.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abpeptidos sinteticos en la induccion de celulas citotoxicas antitumorales\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abpeptidos sinteticos en la induccion de celulas citotoxicas antitumorales\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Alberto P\u00e9rez Mediavilla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Natalia Mar\u00eda Lopez Moratalia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Esteban Santiago Calvo <\/li>\n<li>Javier Diez Martinez (vocal)<\/li>\n<li>Alberto Castilla Cortazar (vocal)<\/li>\n<li>Antonio Brugarolas Masllorens (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Alberto P\u00e9rez Mediavilla Basandonos en la secuencia de la proteina a del staphylococcus aureus cowan i [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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