{"id":14604,"date":"2018-03-09T09:01:22","date_gmt":"2018-03-09T09:01:22","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/vacunacion-contra-un-cancer-de-colon-murino-utilizando-peptidos-inductores-de-respuestas-t-helper-y-t-citotoxicas\/"},"modified":"2018-03-09T09:01:22","modified_gmt":"2018-03-09T09:01:22","slug":"vacunacion-contra-un-cancer-de-colon-murino-utilizando-peptidos-inductores-de-respuestas-t-helper-y-t-citotoxicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/vacunacion-contra-un-cancer-de-colon-murino-utilizando-peptidos-inductores-de-respuestas-t-helper-y-t-citotoxicas\/","title":{"rendered":"Vacunaci\u00f3n contra un c\u00e1ncer de colon murino utilizando peptidos inductores de respuestas t helper y t citotoxicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Noelia Casares Lagar <\/strong><\/h2>\n<p>La inmunization con el epitope t citot\u00f3xico spsyvyhqf (ah1), derivado de la prote\u00edna gp70 de la envuelta del virus de leucemia murino expresado en las c\u00e9lulas tumorales de colon ct26, no protege contra el tumor a los ratones balb\/c. Por el contrario, la inmunizaci\u00f3n con ah1 m\u00e1s los p\u00e9ptidos t helper ova(323-337) o mio(106-118), inductores de perfiles th1 and th0, protegen al 83% y 33% de los animales respectivamente. Curiosamente, la inmunizaci\u00f3n con ah1 y los dos peptidos helper, revirti\u00f3 la eficacia al 33%. Hemos identificado un p\u00e9ptido t helper end\u00f3geno p(320-333) perteneciente a gp70 que induce un perfil th1 y que es naturalmente presentado. Como ocurre con ova (323-337), la inmunizaci\u00f3n con p(320-333) solo no protege a los animales del desarrollo del tumor. Sin embargo, p(320-333) m\u00e1s ah1 protege al 89% de los animales. S\u00f3lo el 20% de los ratones vacunados con ah1 + ova (323-337) o ah1 + p(320-333) quedaron protegidos cuando el tumor se inyect\u00f3 80 d\u00edas tras la inmunizaci\u00f3n con p\u00e9ptidos. El tratamiento con ova(323-337) o con p(320-333) alrededor de tumores establecidos, no fue eficaz y s\u00f3lo un animal de cada grupo elimin\u00f3 el tumor por completo. Nuestros resultados muestran que p\u00e9ptidos inductores de potentes respuestas th1, pertenecientes o no al ant\u00edgeno tumoral, pueden ser \u00fatiles para generar respuestas ctl antitumorales protectoras.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Vacunaci\u00f3n contra un c\u00e1ncer de colon murino utilizando peptidos inductores de respuestas t helper y t citotoxicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Vacunaci\u00f3n contra un c\u00e1ncer de colon murino utilizando peptidos inductores de respuestas t helper y t citotoxicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Noelia Casares Lagar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Borras Cuesta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n<li>balbino Jos\u00e9 Alarcon sanchez (vocal)<\/li>\n<li>dolores Lozano escario (vocal)<\/li>\n<li>Jos\u00e9 Pe\u00f1a Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Noelia Casares Lagar La inmunization con el epitope t citot\u00f3xico spsyvyhqf (ah1), derivado de la prote\u00edna gp70 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,1737,17749,2714],"tags":[15392,46942,18184,15059,13,46941],"class_list":["post-14604","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-inmunologia","category-navarra","category-vacunas","tag-balbino-jose-alarcon-sanchez","tag-dolores-lozano-escario","tag-francisco-borras-cuesta","tag-jesus-m-prieto-valtuena","tag-jose-pena-Martinez","tag-noelia-casares-lagar"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14604","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=14604"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14604\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=14604"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=14604"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=14604"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}