{"id":146051,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/altas-dosis-de-quimioterapia-y-rescate-con-precursores-hematopoyeticos-de-sangre-periferica\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"altas-dosis-de-quimioterapia-y-rescate-con-precursores-hematopoyeticos-de-sangre-periferica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/altas-dosis-de-quimioterapia-y-rescate-con-precursores-hematopoyeticos-de-sangre-periferica\/","title":{"rendered":"Altas dosis de quimioterapia y rescate con precursores hematopoyeticos de sangre periferica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Duni Sawadogo Gnenago <\/strong><\/h2>\n<p>En 43 pacientes con tumores solidos se ha realizado un tratamiento con ado y rescate con phsp. El procedimiento convencional se ha modificado de forma que los phsp se extraen sin movilizacion previa y no se criopreservan los phsp. Se conservan 5 dias en medio liquido a 37 grados c, a razon de 2 x 10 cmn\/m1 de rpmi con o sin gm-csf a 400 u\/ml e il-2 500 u\/m1. En un estudio preliminar \u00abin vitro\u00bb se vio que a lo largo del cultivo en medio liquido no se generan mas cfu-gm o bfu-e. Cuando los phsp se incuban con el gm-csf el porcentaje de cd 34 alcanza 19,6% (p:0,016). No hemos encontrado ninguna correlacion entre el tiempo de aplasia y la riqueza de la muestra a trasplantar en cmn, cfu-gm, cd 34 o cd 33. En un estudio clinico aleatorizado los pacientes recibieron phsp incubados en rpmi con (grupo experimental) o sin (grupo control) gm-csf + il-2.  los pacientes del grupo experimental salen mas pronto de aplasia y tienen menos complicaciones severas. En este grupo no se ha producido tampoco ninguna muerte precoz relacionada con las adq.  este efecto beneficioso de la incubacion de los phsp con citoquinas mas que la proliferacion de las cd 34, se deberia a cambios cualitativos (phsp en el ciclo celular y\/o aumento de las moleculas de adhesion).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Altas dosis de quimioterapia y rescate con precursores hematopoyeticos de sangre periferica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Altas dosis de quimioterapia y rescate con precursores hematopoyeticos de sangre periferica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Duni Sawadogo Gnenago <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Brugarolas Masllorens<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Esteban Santiago Calvo <\/li>\n<li>Oscar Fernandez Hidalgo (vocal)<\/li>\n<li> Subira Bados Mar\u00eda  Luisa (vocal)<\/li>\n<li>Fernando Vidal Vanaclocha (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Duni Sawadogo Gnenago En 43 pacientes con tumores solidos se ha realizado un tratamiento con ado y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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