{"id":146058,"date":"1993-01-01T00:00:00","date_gmt":"1993-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/eficacia-de-la-terapia-antioxidante-en-la-hepatitis-cronica\/"},"modified":"1993-01-01T00:00:00","modified_gmt":"1993-01-01T00:00:00","slug":"eficacia-de-la-terapia-antioxidante-en-la-hepatitis-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/eficacia-de-la-terapia-antioxidante-en-la-hepatitis-cronica\/","title":{"rendered":"Eficacia de la terapia antioxidante en la hepatitis cronica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Suarez Tembra Manuel Antonio <\/strong><\/h2>\n<p>Determinamos los niveles de gsh en plasma (gsh-p) y en celulas mononucleares (cmsp) (gsh-l), utilizando un modelo enzimatico (conjugacion con cdnb), de 100 pacientes con epatitis cronica por vhc y 26 controles sanos. En el grupo no tratado (n-46), los valores de gsh estaban significativamente disminuidos en comparacion con los controles. En los que normalizaron las transaminasas (gpt) durante el tratamiento con interferon (ifn-alfa) (n=25) tenian niveles de gsh significativamente mas altos que los no tratados o en los no respondedores. En los no tratados los bajos niveles de gsh-l se asociaron a la presencia intracelular de las cadenas (+) y (-) del rna viral, indicando la replicacion activa en todos estos casos. En los que despues del ifn-alfa tenian el gsh mas alto, se observo aclaramiento del virus en el 78%. En 8 pacientes no tratados se indico desferrioxamina, incrementandose los valores de gsh-l. Al incubar las cmsp con nac, observamos un aumento significativo de la respuesta mitogenica y de la actividad natural killer. En 10 pacientes no tratados, la administracion de nac, aumento los valores de gsh-l, pero no modifico la gpt y el gsh-p. En 14 pacientes con gpt elevada despues de 4 meses de ifn-alfa, la asociacion de nac, resulto en un descenso marcado de gpt en todos los casos y una completa normalizacion en el 41% despues de 5-6 meses de tratamiento, al igual que el gsh-l. Por tal en la hc-c existe una deplecion del gsh. La nac aumenta la actividad del ifn-alfa. Son necesarios mas estudioso para conocer la eficacia de la terapia antioxidante en esta enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Eficacia de la terapia antioxidante en la hepatitis cronica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Eficacia de la terapia antioxidante en la hepatitis cronica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Suarez Tembra Manuel Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1993<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas M. Prieto Valtue\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Santidrian Alegre <\/li>\n<li>Pilar Civeira Murillo (vocal)<\/li>\n<li>Fernando Pons Romero (vocal)<\/li>\n<li>Javier Diez Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Suarez Tembra Manuel Antonio Determinamos los niveles de gsh en plasma (gsh-p) y en celulas mononucleares (cmsp) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139,17749],"tags":[10548,11773,15059,17764,17969,260983],"class_list":["post-146058","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-navarra","tag-fernando-pons-romero","tag-javier-diez-Martinez","tag-jesus-m-prieto-valtuena","tag-pilar-civeira-murillo","tag-santiago-santidrian-alegre","tag-suarez-tembra-manuel-antonio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/146058","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=146058"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/146058\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=146058"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=146058"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=146058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}