{"id":14613,"date":"2018-03-09T09:01:23","date_gmt":"2018-03-09T09:01:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-oxido-nitrico-durante-la-recirculacion-normotermica-en-el-trasplante-hepatico-experimental-en-cerdos-con-donantes-a-corazon-parado\/"},"modified":"2018-03-09T09:01:23","modified_gmt":"2018-03-09T09:01:23","slug":"papel-del-oxido-nitrico-durante-la-recirculacion-normotermica-en-el-trasplante-hepatico-experimental-en-cerdos-con-donantes-a-corazon-parado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-del-oxido-nitrico-durante-la-recirculacion-normotermica-en-el-trasplante-hepatico-experimental-en-cerdos-con-donantes-a-corazon-parado\/","title":{"rendered":"Papel del oxido nitrico durante la recirculacion normotermica en el trasplante hepatico experimental en cerdos con donantes a corazon parado."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Barros Schelotto Hugo Pablo Luis <\/strong><\/h2>\n<p>Durante la obtenci\u00f3n de higados de donantes a coraz\u00f3n parado la recirculaci\u00f3n normot\u00e9rmica (rn) act\u00faa aumentando los niveles de adenosina circulantes antes de la isquemia-reperfusi\u00f3n. El oxido nitrico (on) mediante su efecto vasodilatdor, es el ultimo efector del mecanismo protector de la rn. Se trasplantaron 40 cerdos, en donde a los animales donantes se los randomizaron de la siguiente manera: grupo 1:20 min. De parada cardiaca (pc) seguidos de 30 minutos de rn previo a enfriamiento corporal total grupo 2:igual al anterior pero bloqueando la sintesis del on con l-name (10 mg\/kg). Durante la rn. Grupo 3:esperminia nonoato(10 mg\/kg).5 minutos antes de los 20 min. de pc. Grupo : infusi\u00f3n de adenosina \/250 ug\/kg). Junto con l-name (10 mg\/kg). Antes de los 20 min. De pc. Antes de la extraccion los higados feuron perfundidos con soluci\u00f3n de wisconsin y preservados a 4\u00c2\u00ba c durante 6 horas. La superviencia en el grupo de rn ha sido del 100% en el grupo donde se administro l-name durante la rn fue del 50% en el grupo de espermina nonoato del 90% y en el grupo de adenosina +l-name del 30% (p menor que 0,05) en todos los grupos existi\u00f3 un ascenso significativo a las 24 horas en los niveles de alat en relaci\u00f3n al valor basal. La alfa-gst aumento significativamente a la hora de la reperfusi\u00f3n en los 4 grupos. Los valores de ah fueron significativamente mayores en los cerdos que se utiliz\u00f3 el l-name durante la rn(p menor que 0,001). la rn act\u00faa de forma beneficiosa a trav\u00e9s de la activaci\u00f3n de la edenosina que determina un aumento de on. Este produce un efecto protector de lecho microvascular, que se traduce en una menor lesion tanto a nivel endotelial y como hepatocelular. El mecanismo de acci\u00f3n, es mas complejo de lo que conocemos, puesto que la aportaci\u00f3n exogena de oxido n\u00edtrico no se traduce en el efecto protector de la rn.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del oxido nitrico durante la recirculacion normotermica en el trasplante hepatico experimental en cerdos con donantes a corazon parado.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del oxido nitrico durante la recirculacion normotermica en el trasplante hepatico experimental en cerdos con donantes a corazon parado. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Barros Schelotto Hugo Pablo Luis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>valdecasas Salgado Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Visa miracle <\/li>\n<li>ramon Charco (vocal)<\/li>\n<li>Juan Figueras (vocal)<\/li>\n<li>ramon Deulofeu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Barros Schelotto Hugo Pablo Luis Durante la obtenci\u00f3n de higados de donantes a coraz\u00f3n parado la recirculaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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