{"id":14664,"date":"2018-03-09T09:01:27","date_gmt":"2018-03-09T09:01:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-isoprenoides-de-la-via-de-sintesis-del-colesterol-en-el-control-de-la-muerte-celular-implicaciones-en-la-lesion-aterosclerotica\/"},"modified":"2018-03-09T09:01:27","modified_gmt":"2018-03-09T09:01:27","slug":"papel-de-los-isoprenoides-de-la-via-de-sintesis-del-colesterol-en-el-control-de-la-muerte-celular-implicaciones-en-la-lesion-aterosclerotica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/papel-de-los-isoprenoides-de-la-via-de-sintesis-del-colesterol-en-el-control-de-la-muerte-celular-implicaciones-en-la-lesion-aterosclerotica\/","title":{"rendered":"Papel de los isoprenoides de la via de sintesis del colesterol en el control de la muerte celular. implicaciones en la lesion aterosclerotica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Miguel Blanco Colio <\/strong><\/h2>\n<p>La enfermedad cardiovascular es la 1\u00aa causa de mortalidad de los pa\u00edses occidentales. La formaci\u00f3n de la placa ateroscler\u00f3tica es debida a un proceso inflamatorio y proliferativo en el que est\u00e1n implicadas tanto c\u00e9lulas residentes en la pared vascular (c\u00e9lulas de m\u00fasculo liso y c\u00e9lulas endoteliales) como c\u00e9lulas inflamatorias (monocitos\/macr\u00f3fagos y linfocitos t). El n\u00famero de c\u00e9lulas de la pared vascular esta implicado en el desarrollo y progresi\u00f3n de las lesiones ateroscler\u00f3ticas. Existen diferentes factores de riesgo cardiovascular entre los que se encuentran los l\u00edpidos. Los f\u00e1rmacos hipolipemiantes y, en concreto, los inhibidores de la hmg-coa reductasa (estatinas), han demostrado una alta eficiencia en reducir la mortalidad debida a eventos coronarios. Sin embargo, los efectos beneficiosos de estos f\u00e1rmacos no pueden ser explicados \u00fanicamente por su acci\u00f3n hipolipemiante y deben de tener acciones independientes de la s\u00edntesis de colesterol.  hemos observado que el tratamiento con diferentes inhibidores de la hmg-coa reductasa da lugar a la muerte celular por apoptosis de c\u00e9lulas de m\u00fasculo liso vascular en cultivo. Este efecto esta relacionado con la inhibici\u00f3n de la s\u00edntesis de isoprenoides y, en particular, con la inhibici\u00f3n de la isoprenilaci\u00f3n de prote\u00ednas g peque\u00f1as y con la disminuci\u00f3n de la expresi\u00f3n de la prote\u00edna proapopt\u00f3tica bcl-2, dando lugar a la activaci\u00f3n de la v\u00eda mitocondrial de muerte celular.  tambi\u00e9n, hemos estudiado la presencia de fas y de su ligando (lfas) en la lesi\u00f3n ateroscler\u00f3tica humana y hemos observado que estas dos prote\u00ednas proapopt\u00f3ticas se expresan preferentemente en la zona con mayor predisposici\u00f3n a la rotura, los hombros. En un modelo de aterosclerosis experimental hemos observado que el tratamiento con un inhibidor de la hmg-coa reductasa, atorvastatina, reduce la presencia de fas y de lfas en la lesi\u00f3n. Adem\u00e1s, el tratamiento con atorvastatina disminuy<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los isoprenoides de la via de sintesis del colesterol en el control de la muerte celular. implicaciones en la lesion aterosclerotica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los isoprenoides de la via de sintesis del colesterol en el control de la muerte celular. implicaciones en la lesion aterosclerotica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Miguel Blanco Colio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Egido De Los Rios<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: arturo Fern\u00e1ndez-cruz p\u00e9rez <\/li>\n<li>Luis Masana mart\u00edn (vocal)<\/li>\n<li>Jes\u00fas Millan nu\u00f1ez cortes (vocal)<\/li>\n<li>Juan Garcia puig (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Miguel Blanco Colio La enfermedad cardiovascular es la 1\u00aa causa de mortalidad de los pa\u00edses occidentales. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,160,115,35,17],"tags":[1777,5119,1552,39034,47107,47106],"class_list":["post-14664","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-quimica","tag-arturo-fernandez-cruz-perez","tag-jesus-egido-de-los-rios","tag-jesus-millan-nunez-cortes","tag-juan-garcia-puig","tag-luis-masana-martin","tag-luis-miguel-blanco-colio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14664","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=14664"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14664\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=14664"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=14664"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=14664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}