{"id":14697,"date":"2018-03-09T09:01:30","date_gmt":"2018-03-09T09:01:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estrategias-quirurgicas-para-disminuir-la-lesion-provocada-por-el-sindrome-de-isquemia-reperfusion-en-un-modelo-de-trasplante-ortotopico-de-higado-en-rata\/"},"modified":"2018-03-09T09:01:30","modified_gmt":"2018-03-09T09:01:30","slug":"estrategias-quirurgicas-para-disminuir-la-lesion-provocada-por-el-sindrome-de-isquemia-reperfusion-en-un-modelo-de-trasplante-ortotopico-de-higado-en-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estrategias-quirurgicas-para-disminuir-la-lesion-provocada-por-el-sindrome-de-isquemia-reperfusion-en-un-modelo-de-trasplante-ortotopico-de-higado-en-rata\/","title":{"rendered":"Estrategias quirurgicas para disminuir la lesion provocada por el sindrome de isquemia-reperfusion en un modelo de trasplante ortot\u00f3pico de higado en rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nicolas Heredia Eduardo <\/strong><\/h2>\n<p>Las sustancias proinflametorias, en las que destaca el factor de necrosis tumoral (tnf), que provienen de la congesti\u00f3n intestinal y espl\u00e9nica y\/o del propio injerto durante la isquemia reperfusi\u00f3n son las responsables de la lesi\u00f3n del injerto hep\u00e1tico y del tejido pulmonar en el trasplante hep\u00e1tico (ht).  esta bien establecida que el shunt portosistemico (sps) es eficaz para evitar la congestion intestinal. El precondicionamiento isqu\u00e9mico (pc) en isquemia normot\u00e9rmica inhibe la s\u00edntesis de tnf por lo tanto reducir\u00eda la lesi\u00f3n hepatica y pulmonar del th. En esta tesis se evalu\u00f3 la posible proteccion, del sps y\/o el pc, frente a a lesi\u00f3n de i\/r provocada en el injerto hepatico y el tejido pulmonar tras el trasplante hepatico.  a las 24 hs de de la reperfusi\u00f3n de un injerto hepatico sometido a 8 h de isquemia fria de objetivo la lesion por i\/r tanto del hepatocito como de la celula endotelial. Estos hallazgos se asociaron con un aumento de los niveles plasm\u00e1ticos de tnf y lesi\u00f3n pulmonar. Cuando se realiz\u00f3 un sps en el receptor se vio protecci\u00f3n de la celula endotelial pero no del hepatocito. Esta tecnica no logro disminuir los niveles plasm\u00e1ticos de tnf ni reducir la lesi\u00f3n pulmonar. En cambio al realizar el pc en el donante se observ\u00f3 una reducci\u00f3n de la lesi\u00f3n tanto en el hepatocito como en la celula endotelial, adem\u00e1s redujo los niveles plasm\u00e1ticos de tnf y disminuyo la lesion pulmonar. Al aplicar abas tecnicas en un mismo trasplante la lesi\u00f3n hepatica, los niveles de tnf y la lesi\u00f3n pulmonar fueron similares a las encontradas tras el th.  el pc podria ser una estrategia v\u00e1lida para reducir el da\u00f1o hep\u00e1tico y pulmonar tras el th pero en algunas circunstancias en las que se requiere utilizar un sps podria no ser efectivo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estrategias quirurgicas para disminuir la lesion provocada por el sindrome de isquemia-reperfusion en un modelo de trasplante ortot\u00f3pico de higado en rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estrategias quirurgicas para disminuir la lesion provocada por el sindrome de isquemia-reperfusion en un modelo de trasplante ortot\u00f3pico de higado en rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nicolas Heredia Eduardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>LLuis Grande Posa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Visa miracle <\/li>\n<li>antoni Rimola (vocal)<\/li>\n<li>Carlos Margarit (vocal)<\/li>\n<li>Alberto Marco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nicolas Heredia Eduardo Las sustancias proinflametorias, en las que destaca el factor de necrosis tumoral (tnf), que 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