{"id":14713,"date":"2018-03-09T09:01:31","date_gmt":"2018-03-09T09:01:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismo-acetilador-en-la-colitis-ulcerosa\/"},"modified":"2018-03-09T09:01:31","modified_gmt":"2018-03-09T09:01:31","slug":"polimorfismo-acetilador-en-la-colitis-ulcerosa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismo-acetilador-en-la-colitis-ulcerosa\/","title":{"rendered":"Polimorfismo acetilador en la colitis ulcerosa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Serrano Gonzalez <\/strong><\/h2>\n<p>El h\u00edgado es el principal reponsable de la detoxificaci\u00f3n de endobi\u00f3ticos y xenobi\u00f3ticos. Para ello, lleva a cabo reacciones enzim\u00e1ticas que podemos dividir en dos tipos o fases: fase i (oxidaciones) y fase ii (glucoronizaci\u00f3n, metilaci\u00f3n y acetilaci\u00f3n). En ambas est\u00e1n descritos polimorfismos, lo que conlleva la existencia de actividad enzim\u00e1tica normal o lenta.  en el enzima arilamina n-acetil transferasa (nat2) se han descrito once mutaciones en el gen codificante del enzima, y como resultado de sus combinaciones, ventiseis varientes al\u00e9licas (la mayoria lentas). Existe un amplia variabilidad en la distribuci\u00f3n \u00e9tnica del car\u00e1cter acetilador lento: asi, oscila entre el 70-90% de los arabes y el 5-20% de orientales. En cauc\u00e1sicos se situa en un termino medio. En espa\u00f1a de diecisiete variantes descubiertas, tres suponen casi un 90%, por orden de frecuencia:nat2*5b, nat2*6a y nat2*4 (wt), siendo lentas las dos primeras. Un 56% de nuestra poblaci\u00f3n sera acetiladora lenta (portadora homocigota de alelos lentos l\/l) y el resto r\u00e1pida, bien homocigota r\/r con el 6% o heterocigota con el 38% restante (r\/l).  estudiamos las implicaciones de este polimorfismo en la eficacia y tolerancia de ciertos farmacos metabolizados por esta via (salazopirina, procainamida, hidralazina, isoniacida).  en lo que respecta a neoplasias se ha descrito una frecuencia del tumor de vejiga en aquellos acetiladores lentos fumadores y\/o expuestos a aminas aromaticas cancer\u00edgenas (se exponen los posibles mecanismos) as\u00ed como de acetiladores r\u00e1pidos en el c\u00e1ncer gastrico. No hay datos concluyentes en los de v\u00edas respiratorias y pulm\u00f3n, otros digestivos y en los de mama.  en la enfermedad de parkinson de inicio precoz hay predominio de los r\u00e1pidos. En la de alzheimer hay m\u00e1s alta frecuencia del alelo funcionante y m\u00e1s baja de los recesivos 6a y 5b. No se demuestra relaci\u00f3n con la diabetes mellitus, lupus. Artritis reumatoide y esclerosis m\u00fal<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismo acetilador en la colitis ulcerosa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismo acetilador en la colitis ulcerosa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Serrano Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Ladero Quesada<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Portugal <\/li>\n<li>Juan Herrerias (vocal)<\/li>\n<li>julio Benitez (vocal)<\/li>\n<li>ricardo Moreno otero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Serrano Gonzalez El h\u00edgado es el principal reponsable de la detoxificaci\u00f3n de endobi\u00f3ticos y xenobi\u00f3ticos. Para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139],"tags":[6504,47239,47240,47241,47238,13202],"class_list":["post-14713","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","tag-jose-maria-ladero-quesada","tag-jose-portugal","tag-juan-herrerias","tag-julio-benitez","tag-manuel-serrano-gonzalez","tag-ricardo-moreno-otero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=14713"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14713\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=14713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=14713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=14713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}