{"id":14761,"date":"2018-03-09T09:01:35","date_gmt":"2018-03-09T09:01:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/participacion-del-glutamato-y-las-poliaminas-en-el-funcionamiento-de-los-ganglios-basales-una-aproximacion-experimental-y-cla%c2%adnica\/"},"modified":"2018-03-09T09:01:35","modified_gmt":"2018-03-09T09:01:35","slug":"participacion-del-glutamato-y-las-poliaminas-en-el-funcionamiento-de-los-ganglios-basales-una-aproximacion-experimental-y-cla%c2%adnica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/participacion-del-glutamato-y-las-poliaminas-en-el-funcionamiento-de-los-ganglios-basales-una-aproximacion-experimental-y-cla%c2%adnica\/","title":{"rendered":"Participaci\u00f3n del glutamato y las poliaminas en el funcionamiento de los ganglios basales. una aproximaci\u00f3n experimental y cl\u00ednica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Meritxell Viv\u00f3 Abelairas <\/strong><\/h2>\n<p>Las poliaminas est\u00e1n involucradas en lesiones agudas pero est\u00e1 por esclarecer si se ven implicadas en procesos neurodegenerativos. Por otro lado, el glutamato act\u00faa como neurotransmisor en el circuito neuronal de los ganglios basales y podr\u00eda intervenir tambi\u00e9n en las patolog\u00edas neurodegenerativas a trav\u00e9s de la excitotoxicidad.  los niveles tisulares de la poliamina putrescina (put) y del enzima ornitina descarboxilas\u00e1 (odc) incrementan en respuesta a lesiones agudas. se ha establecido que la administraci\u00f3n intraestriatal de \u00e1cido ca\u00ednico induce, paralelamente al incremento de put tisular y de odc-ir neuronal, un incremento en la concentraci\u00f3n de put extracelular.  el an\u00e1lisis de muestras de cerebro humano procedentes de pacientes de enfermedad de parkinson (ep), par\u00e1lisis supranuclear progresiva o enfermedad de huntington (eh) mostr\u00f3 que las poliaminas no modifican los niveles de tejido a excepci\u00f3n de la eh, en la que se observ\u00f3 una disminuci\u00f3n en los niveles de espermina en los n\u00facleos caudado y putamen, caracter\u00edsticamente atrofiados en esta enfermedad. La poliaminas mostraron un distribuci\u00f3n heterog\u00e9nea en los ganglios basales y, adem\u00e1s, se observ\u00f3 una correlaci\u00f3n negativa entre la edad y los niveles de espermina y espermidina.  la ep se caracteriza por la p\u00e9rdida de c\u00e9lulas dopamin\u00e9rgicas en la sustancia negra pars compacta (snc). Estas c\u00e9lulas expresan los receptores glutamat\u00e9rgicos de la familia del cainato glur5. La administraci\u00f3n local del agonista glur5 atpa indujo una disminuci\u00f3n en el n\u00famero de c\u00e9lulas th-ir de la snc. La respuesta rotacional a la administraci\u00f3n de atpa y de agonistas dopamin\u00e9rgicos fue indicativa del grado de da\u00f1o producido.  el glutamato, actuando como neurotransmissor, regula el circuito de los ganlios basales. A partir de los niveles extracelulares de gaba del n\u00facleo p\u00e1lido bentral y de los cambios comportamentales en la actividad motora inducida por pcp, encontra<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Participaci\u00f3n del glutamato y las poliaminas en el funcionamiento de los ganglios basales. una aproximaci\u00f3n experimental y cl\u00ednica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Participaci\u00f3n del glutamato y las poliaminas en el funcionamiento de los ganglios basales. una aproximaci\u00f3n experimental y cl\u00ednica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Meritxell Viv\u00f3 Abelairas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emili Mart\u00ednez Hermida<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago (secretario) Ambrosio viale <\/li>\n<li>joan Serratosa (vocal)<\/li>\n<li>m. Canals josep (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Meritxell Viv\u00f3 Abelairas Las poliaminas est\u00e1n involucradas en lesiones agudas pero est\u00e1 por esclarecer si se ven [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,9,189,483,156,1323],"tags":[47384,47386,47387,47383,47385],"class_list":["post-14761","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-medicas","category-farmacodinamia","category-mecanismos-de-accion-de-los-farmacos","category-patologia","category-patologia-experimental","tag-emili-Martinez-hermida","tag-joan-serratosa","tag-m-canals-josep","tag-meritxell-vivo-abelairas","tag-santiago-secretario-ambrosio-viale"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=14761"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/14761\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=14761"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=14761"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=14761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}