{"id":14801,"date":"2018-03-09T09:01:39","date_gmt":"2018-03-09T09:01:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/protea%c2%adnas-reguladoras-del-complemento-y-enfermedad-infecciones-piogenicas-y-sa%c2%adndrome-hemola%c2%adtico-uremico\/"},"modified":"2018-03-09T09:01:39","modified_gmt":"2018-03-09T09:01:39","slug":"protea%c2%adnas-reguladoras-del-complemento-y-enfermedad-infecciones-piogenicas-y-sa%c2%adndrome-hemola%c2%adtico-uremico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/protea%c2%adnas-reguladoras-del-complemento-y-enfermedad-infecciones-piogenicas-y-sa%c2%adndrome-hemola%c2%adtico-uremico\/","title":{"rendered":"Prote\u00ednas reguladoras del complemento y enfermedad: infecciones piog\u00e9nicas y s\u00edndrome hemol\u00edtico ur\u00e9mico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David P\u00e9rez Caballero <\/strong><\/h2>\n<p>El sistema del complemento engloba un conjunto de m\u00e1s de 30 prote\u00ednas distribuidas tanto en fase fluida como en la superficie de las c\u00e9lulas y constituye una parte importante de la inmunidad innata. Su funci\u00f3n principal es la eliminaci\u00f3n de microorganismos, aunque tambi\u00e9n posee otras funciones biol\u00f3gicas importantes. Este sistema es r\u00e1pido pero por su baja especificidad requiere prote\u00ednas reguladoras que evitan su activaci\u00f3n sobre los tejidos propios. La importancia de las prote\u00ednas reguladoras se reflejan en que situaciones de disfunci\u00f3n de estas prote\u00ednas, su ausencia por deficiencia gen\u00e9tica, o la utilizaci\u00f3n que hacen de ellas algunos organismos, son la causa de enfermedades muy graves. Entre estas enfermedades se encuentran tanto infecciones recurrentes (streptococcus pyogenes) como enfermedades cr\u00f3nicas (s\u00edndrome hemol\u00edtico ur\u00e9mico).  streptococcus pyogenes es una bacteria gram positiva que produce numerosas enfermedades leves de la piel y del tracto respiratorio superior, que al hacerse cr\u00f3nicas pueden originar secuelas postestreptoc\u00f3cicas muy graves como la fiebre reum\u00e1tica aguda o la glomerulonefritis aguda. Ocasionalmente, s.Pyogenes puede producir enfermedades invasivas serias como la fascitis necrotizante o el s\u00edndrome de choque t\u00f3xico. El factor de virulencia mejor caracterizado presente en la superficie bacteriana es la prote\u00edna m. Esta prote\u00edna participa en adhesi\u00f3n y posee propiedades antifagoc\u00edticas. Se ha sugerido que las propiedades antifagoc\u00edticas de prote\u00edna m se deben a la interacci\u00f3n de prote\u00ednas plasm\u00e1ticas como los reguladores de complemento c4bp, factor h y fhl-1. El objetivo de este trabajo de tesis ha sido profundizar en las interaciones entre reguladores del complemento y s.Pyogenes.  las conclusiones a las que se han llegado son:  1,- la uni\u00f3n de los reguladores del complemento c4bp, factor h y fhl-1 es espec\u00edfica de serotipo.  2,- el 50% de los aislados cl\u00ednicos analiza<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Prote\u00ednas reguladoras del complemento y enfermedad: infecciones piog\u00e9nicas y s\u00edndrome hemol\u00edtico ur\u00e9mico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Prote\u00ednas reguladoras del complemento y enfermedad: infecciones piog\u00e9nicas y s\u00edndrome hemol\u00edtico ur\u00e9mico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David P\u00e9rez Caballero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Santiago Rodriguez De Cordoba<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio L\u00f3pez de castro <\/li>\n<li>sebastian Alberti serrano (vocal)<\/li>\n<li>Fernando Vivanco mart\u00ednez (vocal)<\/li>\n<li>Santiago Lamas pel\u00e1ez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David P\u00e9rez Caballero El sistema del complemento engloba un conjunto de m\u00e1s de 30 prote\u00ednas distribuidas tanto [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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